Results 21 to 30 of about 2,864 (178)
Journal of Taibah University for Science, 2021 The role of hyperforin in combination anticancer therapy remain unknown. In this study, several doses of combination treatment (paclitaxel and hyperforin) were introduced to the Michigan Cancer Foundation (MCF)-7 cell culture for 24 h.
Muttiah Barathan +4 more
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Molecules, 2023 Oxidative stress and the hypoxic microenvironment play a key role in the progression of human melanoma, one of the most aggressive skin cancers. The aim of our study was to evaluate the effect of Hypericum perforatum extracts of different origins (both ...
Aleksandra Brankiewicz +8 more
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Journal of Taibah University for Science, 2023 Breast cancer has been recorded as a frequent malignant cancer. The side effects of current chemotherapy drugs are still a severe problem. Hence, naturally occurring phytochemicals can be a possible solution to overcome this issue.
Muttiah Barathan +7 more
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Hyperforin Inhibits Cancer Invasion and Metastasis [PDF]
Cancer Research, 2004 AbstractHyperforin (Hyp), the major lipophilic constituent of St. John’s wort, was assayed as a stable dicyclohexylammonium salt (Hyp-DCHA) for cytotoxicity and inhibition of matrix proteinases, tumor invasion, and metastasis. Hyp-DCHA triggered apoptosis-associated cytotoxic effect in both murine (C-26, B16-LU8, and TRAMP-C1) and human (HT-1080 and SK-
DONA M +10 more
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Van Tıp Dergisi, 2018 INTRODUCTION: Inflammation is an innate immune response that protects host organism from external injuries and pathogens. The increased inflammatory response in organism can cause many diseases, especially cancer.
Mehmet Berköz +2 more
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The Total Synthesis of Hyperforin [PDF]
Synlett, 2016 Hyperforin has remained a popular and challenging synthetic target since its isolation over forty years ago. As a result, numerous synthetic strategies and ring-forming reactions have been developed to address its formidable molecular architecture. Herein we describe our contributions to this area resulting in a ten-step synthetic pathway enabled by a ...
Thomas Maimone, Chi Ting
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"In vitro" study of the mode of action of antidepressants in cell culture models : comparison of the effects of "Hypericum perforatum L." extracts and classical synthetic compounds on the [beta]-adrenergic signal pathway [PDF]
, 2005 The clinical effectiveness of the plant extract of Hypericum perforatum L. in treating mild to moderate depression is well established. The extract shows a more favourable side effect profile than other antidepressant drugs, like tricyclics and selective
Wirz, Adrian
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Molecules, 2020 St. John’s wort (Hypericum perforatum L.) is a medicinal plant that alleviates depression and other disorders due to its abundance of active ingredients. Hyperforin, rutin, and melatonin are the main active, and important, ingredients in St.
Chia-Hung Kuo +4 more
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BIOLOGICAL ACTIVITY OF HYPERICUM PERFORATUM L. (HYPERICACEAE): A REVIEW
Фармация и фармакология (Пятигорск), 2021 Hypericum perforatum L. (St. John's wort) is a medicinal plant that has been intensivly studied by clinicians, pharmacologists, and chemists. It has resulted in the publication of both original articles and a number of, reviews devoted to the general ...
A. L. Budantsev +3 more
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Pharmaceuticals, 2023 Any defects in bile formation, secretion, or flow may give rise to cholestasis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is multifactorial, targeting parallel pathways potentially increases the ...
Ala Mohagheghzadeh +3 more
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