Results 21 to 30 of about 4,383 (214)
Pharmaceuticals, 2023 Any defects in bile formation, secretion, or flow may give rise to cholestasis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is multifactorial, targeting parallel pathways potentially increases the ...
Ala Mohagheghzadeh +3 more
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Cellular neurobiology of hyperforin
Phytotherapy Research, 2023 AbstractHyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro‐apoptotic, antiproliferative, and anti‐inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential ...
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Bigel formulations of St. John’s wort extract in wound healing: toxicological aspects
Biotechnology & Biotechnological Equipment, 2023 This study aimed to investigate the toxicological profile of hyperforin (HP) in silico and to assess it in vivo after topical application of an HP-rich St. John’s wort (SJW) extract. The former analysis predicted low toxicity because of HP’s inability to
Yoana Sotirova +8 more
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Expression and function of transient receptor potential channels in the female bovine reproductive tract [PDF]
, 2016 © 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions.
Atkin, Stephen L. +3 more
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Van Tıp Dergisi, 2018 INTRODUCTION: Inflammation is an innate immune response that protects host organism from external injuries and pathogens. The increased inflammatory response in organism can cause many diseases, especially cancer.
Mehmet Berköz +2 more
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Journal of Taibah University for Science, 2023 Breast cancer has been recorded as a frequent malignant cancer. The side effects of current chemotherapy drugs are still a severe problem. Hence, naturally occurring phytochemicals can be a possible solution to overcome this issue.
Muttiah Barathan +7 more
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Endocrinological effects of high-dose Hypericum perforatum extract WS 5570 in healthy subjects [PDF]
, 2004 In this single-blind study, the effects of acute oral administration of high-dose Hypericum perforatum extract WS 5570 on the cortisol ( COR), adrenocorticotropic hormone ( ACTH), growth hormone (GH), and prolactin (PRL) secretions were examined in 12 ...
Baghai, Thomas C. +3 more
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POTENTIAL ANTICLASTOGENIC EFFECT OF HYPERFORIN [PDF]
Military Medical Science Letters, 2013 Summary Hyperforin is a prenylated phloroglucinol derivative which occurs in the plant Hypericum perforatum L. It has several medicinally important properties (antidepressant, anti-inflammatory, proapoptotic, antibacterial and antiangiogenic). To enable its medicinal use, it is necessary to investigate its potential genotoxic effect on human cell lines.
Petronela Imreová +4 more
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NMDA Receptor-Antagonistic Properties of Hyperforin, a Constituent of St. John’s Wort
Journal of Pharmacological Sciences, 2006 Extracts of the medicinal plant St. John’s wort (Hypericum perforatum) are widely used for the treatment of affective disorders. Hyperforin, a constituent of St. John’s wort, is known to modulate the release and re-uptake of various neurotransmitters, an
Vikas Kumar +6 more
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Regiodivergent photocyclization of dearomatized acylphloroglucinols: asymmetric syntheses of (—)-nemorosone and (—)-6-epi-garcimultiflorone A [PDF]
, 2019 Regiodivergent photocyclization of dearomatized acylphloroglucinol substrates has been developed to produce type A polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives using an excited-state intramolecular proton transfer (ESIPT) process ...
Boyce, Jonathan H. +4 more
core +1 more source