Results 11 to 20 of about 4,383 (214)

Enantioselective Total Synthesis of Hyperforin [PDF]

Journal of the American Chemical Society, 2014
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3 ...
Moebius, David C., Shair, Matthew David, Sparling, Brian Andrew   +2 more
core   +5 more sources

Transplacental passage of hyperforin, hypericin, and valerenic acid

Frontiers in Pharmacology, 2023
Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St.
Deborah Spiess, Deborah Spiess, Vanessa Fabienne Abegg, Antoine Chauveau, Joshua Rath, Andrea Treyer, Michael Reinehr, Sabrina Kuoni, Mouhssin Oufir, Olivier Potterat, Matthias Hamburger, Ana Paula Simões-Wüst   +11 more
doaj   +3 more sources

Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial. [PDF]

Clin Exp Dent Res
ABSTRACT Objectives Hypericum perforatum L. offers several beneficial effects, for example antioxidant, antitumor, wound healing. Our aim was to ascertain the effect of H. perforatum extract gum on salivary Streptococcus mutans count, pH, plaque index, and gingival bleeding. Materials and Methods A total of 54 participants were assigned into two groups
Jamali A, Hamishehkar H, Memar MY, Mousavi Kalajahi SE, Kouhsoltani M, Kosari-Nasab M.   +5 more
europepmc   +2 more sources

Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model. [PDF]

Brain Behav
‐ ABSTRACT Study Objective St. John's wort (Hypericum perforatum) has been used for centuries as a medicinal plant to remedy external disorders such as burns and wounds, as well as internal disorders such as nerve pain, anxiety, and depression. Bone marrow mesenchymal stem cells (BMSCs) are a heterogeneous population of pluripotent stromal cells that ...
Farzadmanesh H, Sameni H, Ghanbari A, Vafaei AA, Khaleghian A, Mirmohammadkhani M, Ghahari L, Shokri A, Safari M.   +8 more
europepmc   +2 more sources

Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons. [PDF]

CNS Neurosci Ther
T3 loss in congenital hypothyroidism (CH) downregulates TRPC6 in dentate granule cells (DGCs), which reduces dendritic spine density via the CaMKIV/CREB signaling pathway. TRPC6 agonist hyperforin rescues DGCs' dendritic spines and cognitive function of CH pups.
Li T, Shen F, Li L, Chen P, Zhu Z, Zheng Y, Li H, Suo G, Wang Y, Shi J, Wu Y.   +10 more
europepmc   +2 more sources

Acute mania and psychosis potentially triggered by St John's wort. [PDF]

PCN Rep
Abstract Background St John's wort (SJW) is widely used as an herbal supplement for depressive symptoms and is generally regarded as safe. However, although extremely rare, manic and psychotic reactions have been reported, typically in individuals taking high doses, using psychotropic agents, or having a psychiatric history. Case Presentation We report
Yoshioka D, Yamanashi T, Iwata M.
europepmc   +2 more sources

Men reporting lasting longer with hyperforin [PDF]

International Brazilian Journal of Urology, 2008
Dapoxetine, a new short lasting selective serotonin reuptake inhibitor (SSRI), has demonstrated clinical efficacy in clinical trials when used immediately before intercourse [1]. However, Dapoxetine has not yet been approved by the regulatory agency in part because of concern of risk and benefit ration of a SSRI in this quality of life condition.
Dae Kyung Kim, Michael B Chancellor
doaj   +6 more sources

Hyperforin Inhibits Cancer Invasion and Metastasis [PDF]

Cancer Research, 2004
AbstractHyperforin (Hyp), the major lipophilic constituent of St. John’s wort, was assayed as a stable dicyclohexylammonium salt (Hyp-DCHA) for cytotoxicity and inhibition of matrix proteinases, tumor invasion, and metastasis. Hyp-DCHA triggered apoptosis-associated cytotoxic effect in both murine (C-26, B16-LU8, and TRAMP-C1) and human (HT-1080 and SK-
DONA M, DELL'AICA I, PEZZATO E, SARTOR L, CALABRESE, FIORELLA, DELLA BARBERA M, DONELLA, ARIANNA, APPENDINO G, BORSARINI A, CANIATO, ROSAMARIA, GARBISA, SPIRIDIONE   +10 more
openaire   +2 more sources

The Influence of Ethanolic Extract of Hypericum Perforatum (St. John's wort) on Growth Performance, Serum Metabolites, Fat Deposition, Immunity, and Lipid Peroxidation in Broiler Chickens. [PDF]

Vet Med Sci
ABSTRACT Background Having bioactive components such as hypericin, hyperforin and quercetin has enabled Hypericum perforatum (HP) to show antioxidant, antiviral and hypocholesterolemic effects in different animal species. Objectives This study aimed to investigate the effects of different levels of Hypericum perforatum extract (HPE) additions on ...
Behroozilak MA, Moftakharzadeh SA, Behroozlak M, Vahedi V, Bakhshalizadeh S.   +4 more
europepmc   +2 more sources

Exploring Multi-Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far. [PDF]

Biotechnol Bioeng
ABSTRACT Three‐dimensional (3D) in vitro cell culture models have revolutionized biomedical research by mimicking the complex 3D in vivo environment in the human body. Different types of 3D models have been established, including heterotypic systems such as, organ‐on‐a‐chips which have been further developed into multiorgan‐on‐chip systems that ...
Abokor FA, Al Yazeedi S, Baher JZ, Cheung C, Sin DD, Osei ET.   +5 more
europepmc   +2 more sources