Results 11 to 20 of about 2,864 (178)
Total Synthesis of Hyperforin [PDF]
Synfacts, 2013 Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique mechanism of action and may be a critical lead for the treatment of depression and possibly other human diseases.
Sparling, Brian Andrew
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Cellular neurobiology of hyperforin
Phytotherapy Research, 2023 AbstractHyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro‐apoptotic, antiproliferative, and anti‐inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential ...
Bouron, Alexandre
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Enantioselective Total Synthesis of Hyperforin [PDF]
Journal of the American Chemical Society, 2012 A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.
Sparling, Brian Andrew +2 more
openaire +6 more sources
Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice [PDF]
Frontiers in Molecular Neuroscience, 2018 N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways.
Bartłomiej Pochwat +11 more
doaj +2 more sources
NMDA Receptor-Antagonistic Properties of Hyperforin, a Constituent of St. John’s Wort
Journal of Pharmacological Sciences, 2006 Extracts of the medicinal plant St. John’s wort (Hypericum perforatum) are widely used for the treatment of affective disorders. Hyperforin, a constituent of St. John’s wort, is known to modulate the release and re-uptake of various neurotransmitters, an
Vikas Kumar +6 more
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Hyperforin Promotes Post-stroke Neuroangiogenesis via Astrocytic IL-6-Mediated Negative Immune Regulation in the Ischemic Brain [PDF]
Frontiers in Cellular Neuroscience, 2019 Hyperforin has been shown to be capable of promoting angiogenesis and functional recovery after ischemic stroke in our previous study. However, the exact mechanisms involved are not fully elucidated.
Hua Yao +16 more
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Frontiers in Immunology, 2021 Hyperforin is a major active constituent of Hypericum perforatum L. extract, which is widely used for the treatment of depressive disorders. Recent studies have reported that hyperforin reduced inflammation in stroke and suppressed proliferation and ...
Song Zhang +10 more
doaj +1 more source
Hypericum perforatum: Traditional uses, clinical trials, and drug interactions [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Hypericum perforatum (Hypericaceae), known as Saint John’s wort (SJW), has been used in different systems of traditional medicine such as Chinese traditional medicine, Greek traditional medicine, and Islamic traditional medicine. The plant and its active
Seyedeh Zahra Nobakht +4 more
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Tetrahydrohyperforin and octahydrohyperforin are two new potent inhibitors of angiogenesis. [PDF]
PLoS ONE, 2010 We have previously shown that hyperforin, a phloroglucinol derivative found in St. John's wort, behaves as a potent anti-angiogenic compound. To identify the reactive group(s) mainly involved in this anti-angiogenic effect, we have investigated the anti ...
Beatriz Martínez-Poveda +4 more
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Plant Direct, 2021 Hyperforin, a major bioactive constituent of Hypericum concentration, is impacted by various phenological phases and soil characteristics. We aimed to design a model predicting hyperforin content in Hypericum perforatum based on different ecological and ...
Maryam Saffariha +2 more
doaj +1 more source