Results 111 to 120 of about 4,765 (201)

Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae [PDF]

The Lancet Infectious Diseases, 2018
Pengcheng, Du, Yuanyuan, Zhang, Chen, Chen   +2 more
  +9 more sources

Comparative genomics of carbapenem resistance and virulence associated with respiratory tract and bloodstream infections in carbapenem-resistant Klebsiella pneumoniae

Virulence
The convergence of resistance and hypervirulence in Klebsiella pneumoniae poses a severe global health threat, yet the genomic mechanisms underlying adaptation to different clinical source remain incompletely understood. We conducted longitudinal genomic
Qian Liu, Hong Shen, Xi Chen, Chunxia Yang, Li Gu, Hui Yuan, Wentao Zhu   +6 more
doaj   +1 more source

A Step Forward in Hypervirulent Klebsiella pneumoniae Diagnostics

Emerging Infectious Diseases
Hypervirulent Klebsiella pneumoniae (hvKp) can cause life-threatening infections in healthy community members. HvKp infections often involve multiple sites, some of which are unusual for classical K. pneumoniae (cKp) infections, such as the central nervous system, eyes, and fascia.
Thomas A. Russo, Francois Lebreton, Patrick T. McGann   +2 more
openaire   +3 more sources

Hypervirulent knockout [PDF]

Genome Biology, 2001
openaire   +1 more source

The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates

, 2010
Streptococcus agalactiae (group B streptococcus; GBS) is a normal constituent of the intestinal microflora and the major cause of human neonatal meningitis. A single clone, GBS ST-17, is strongly associated with a deadly form of the infection called late-
Trieu-Cuot, Patrick, Tazi, Asmaa, Patrick Trieu-Cuot, Bouaboud, Abdelouhab, Bellais, Samuel, Dramsi, Shaynoor, Michel-Yves Mistou, Claire Poyart, Lecuit, Marc, Tardieux, Isabelle, Poyart, Claire, Nicolas Dmytruk, Mechler, Charlotte, Olivier Disson, Samuel Bellais, Dmytruk, Nicolas, Mistou, Michel-Yves, Marc Lecuit, Asmaa Tazi, Shaynoor Dramsi, Huot Khun, Isabelle Tardieux, Disson, Olivier, Abdelouhab Bouaboud, Charlotte Mechler, Khun, Huot   +25 more
core   +1 more source

Genomic epidemiology of dual carbapenemase-producing Klebsiella pneumoniae and identification of an ST23-KL1 blaKPC-2/blaIMP-4 co-producing isolate in a Chinese tertiary hospital

Frontiers in Microbiology
The convergence of hypervirulence and multidrug resistance in K. pneumoniae poses a serious and emerging threat to global health. Here, we conducted genomic characterization of 40 dual carbapenemase-producing K. pneumoniae (DC-KP) isolates collected from
Haijun Li, Haijun Li, Saiqi Qi, Jilei Ma, Cailin Liu, Cailin Liu, Haiyang Meng, Fence Li, Xiaoxu Ma, Wanhai Wang, Wanhai Wang, Shijun Sun, Shijun Sun   +12 more
doaj   +1 more source

Phenotypic and genotypic characterization of extended-spectrum β-lactamase-producing hypervirulent Klebsiella pneumoniae isolates from a tertiary care hospital in Haryana, India

MGM Journal of Medical Sciences
Background: The increasing prevalence of multidrug-resistant (MDR) hypervirulent Klebsiella pneumoniae poses a major therapeutic challenge because the convergence of enhanced virulence and extensive antimicrobial resistance results in severe, difficult ...
Shristi Tiwari, Mukesh Sharma, Moumita Sardar, Leimapokpam Sumitra Devi   +3 more
doaj   +1 more source

The Identification and Characterization of Anti-Virulence Genes Within Candida albicans Phospholipid Biosynthetic Pathways [PDF]

, 2019
Human fungal pathogens, which cause approximately two million life-threatening infections annually, represent a leading cause of morbidity and mortality for immunocompromised individuals.
Tams, Robert
core  

Insertion sequences accelerate genomic convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae via capsular phase variation

Background The convergence of resistance and hypervirulence in Klebsiella pneumoniae represents a significant public health threat, driven by the horizontal transfer of plasmids. Understanding factors affecting plasmid transfer efficiency is essential to
Gang Zhang, Jie Feng, Da-Wei Wei, Jiangqing Huang, Xueru Tian, Chao Wang, Yuqin Song, Yi Li, Linhuan Wu, Qi Chen   +9 more
core   +1 more source

Multicenter Surveillance of Klebsiella pneumoniae: Resistance Shifts, CRKP Prevalence and Hypervirulent Evolution Trajectories in Hebei, China (2019-2023)

Infection and Drug Resistance
Kaiyue Xu,1,2,* Shiying Fan,3,* Ziye Liu,4,* Cuixin Qiang,1,5,6 Jiansheng Wang,7 Pu Qin,1,5,6 Ziyuan Mao,4 Ya Wu,2 Zhirong Li,1,5,6 Jianhong Zhao1,5,6 1Hebei Provincial Center for Clinical Laboratories, The Second Hospital of ...
Xu K, Fan S, Liu Z, Qiang C, Wang J, Qin P, Mao Z, Wu Y, Li Z, Zhao J   +9 more
doaj