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The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu +15 more
wiley +1 more source
The plant pathogen Botrytis cinerea is responsible for gray-mold disease, which infects a wide variety of species. The outcome of this host-pathogen interaction, a result of the interplay between plant defense and fungal virulence pathways, can be ...
Esteban Vasquez-Montaño +4 more
doaj +1 more source
Improved G-AgarTrap: A highly efficient transformation method for intact gemmalings of the liverwort Marchantia polymorpha [PDF]
Liverworts are key species for studies of plant evolution, occupying a basal position among the land plants. Marchantia polymorpha has emerged as a highly studied model liverwort, and many relevant techniques, including genetic transformation, have been ...
Ezura Hiroshi +3 more
core +2 more sources
Klebsiella pneumoniae isolate KPNW showed resistance to all clinically relevant antibiotics. Upon whole genome sequencing and characterization, we detected a large number of antimicrobial resistance genes, resistance‐associated point mutations, virulence determinants, heavy metal resistance genes, and mobile genetic elements in errorits genome ...
Md. Wahid Murad +3 more
wiley +1 more source
Clostridium difficile infections (CDI) have emerged as a major cause of healthcare associated disease, and recent epidemiological evidence also suggests an important role in community-acquired diarrhea. This increase is associated with specific types, especially PCR ribotypes 027 and 078, which are sometimes referred to as "hypervirulent".
openaire +3 more sources
Klebsiella pneumoniae dominates among the pathogens that cause healthcare-associated infections and closely associated with high mortality of patients undergoing heart surgery. K. pneumoniae spp.
M. V. Kuznetsova +3 more
doaj +1 more source
IntroductionKlebsiella pneumoniae can cause a wide range of infections. Hypervirulent K. pneumoniae (hvKp), particularly associated with the K1 and K2 capsular types, is an increasingly significant microorganism with the potential to cause invasive ...
Jaehyeon Lee +9 more
doaj +1 more source
Investigations on Aspergillus fumigatus double-stranded RNAs and their effects on the fungus
The aim of this research was to assess the incidence of dsRNA mycoviruses in the opportunistic human pathogenic fungus Aspergillus fumigatus, where previously no dsRNA viruses had been reported and to investigate the effects of any dsRNAs on the growth
Bhatti, Muhammad Faraz +1 more
core +1 more source
High-throughput analysis of Yersinia pseudotuberculosis gene essentiality in optimised in vitro conditions, and implications for the speciation of Yersinia pestis. [PDF]
BACKGROUND: Yersinia pseudotuberculosis is a zoonotic pathogen, causing mild gastrointestinal infection in humans. From this comparatively benign pathogenic species emerged the highly virulent plague bacillus, Yersinia pestis, which has experienced ...
Atkins, Helen S +4 more
core +2 more sources
Mycoviral infection can either be asymptomatic or have marked effects on fungal hosts, influencing them either positively or negatively. To fully understand the effects of mycovirus infection on the fungal host, transcriptomic profiling of four Beauveria
Charalampos Filippou +4 more
doaj +1 more source

