Enhanced hypocrellin production of Shiraia sp. SUPER-H168 by overexpression of alpha-amylase gene. [PDF]
PLoS ONE, 2018 Relative expression levels of twenty-four amylase genes in Shiraia sp. SUPER-H168 were investigated by real-time quantitative PCR when various carbohydrates, including glucose, sucrose, maltose, amylose, amylopectin and corn flour, were used as carbon ...
Ruijie Gao +7 more
doaj +2 more sources
Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects [PDF]
Frontiers in Immunology, 2023 Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural
Xiaoyun Wang +11 more
doaj +2 more sources
Biotechnology & Biotechnological Equipment, 2016 Hypocrellins is regarded as the new generation of potential photosensitizer in the photodynamic therapy. However, the current production of HA in large quantity is limited, whether extracted from the fruit bodies of Hypcrella bambusae and Shiraia ...
Xiao-Ye Shen +3 more
doaj +2 more sources
Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures [PDF]
MycologyHypocrellins, a group of naturally occurring perylenequinone pigments produced by Shiraia bambusicola, are notable for their potential use in photodynamic therapy (PDT) for treating cancers and viruses.
Xin Ping Li +3 more
doaj +2 more sources
Temperature-responsive regulation of the fermentation of hypocrellin A by Shiraia bambusicola (GDMCC 60438) [PDF]
Microbial Cell Factories, 2022 Background Hypocrellin A (HA) is a perylene quinone pigment with high medicinal value that is produced by Shiraia bambusicola Henn. (S. bambusicola) and Hypocrella bambusae (Berk. & Broome) Sacc.
Yongdi Wen +4 more
doaj +2 more sources
Photodynamic Antifungal Activity of Hypocrellin A Against Candida albicans
Frontiers in Microbiology, 2019 Many studies have reported that hypocrellin A (HA) exhibits effective antimicrobial activities with proper irradiation. However, its antifungal activity and the involved mechanism have not been fully defined.
Ke Xu, Jue Wang, Yingzhi Zhuge
exaly +3 more sources
Natural Photosensitizers in Cancer Therapy: A Chemo-Biodiversity Perspective on Light-Activated Natural Compounds. [PDF]
Chem BiodiversNatural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Baidoo I, Abrahamse H, George BP.
europepmc +2 more sources
Hypocrellin: A Natural Photosensitizer and Nano-Formulation for Enhanced Molecular Targeting of PDT of Melanoma. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolNanotechnology and combination with natural photosensitizers are a prospective means of controlling cancer. Studies on photodynamic therapy (PDT) have shown that improvements in drug administration are required in order to preserve or enhance the mechanistic cell killing effects of PDT on malignant cells.
Gugu Nkosi PW, Chandran R, Abrahamse H.
europepmc +2 more sources
HYPOCRELLINS and THEIR USE IN PHOTOSENSITIZATION* [PDF]
Photochemistry and Photobiology, 1990 Abstract— Hypocrellins A and B are pigments which are isolated from parasitic fungi Hypocrella bambuase (B. et Br) sacc. and Shiraia bambusicola P. Heen found in the People's Republic of China (P.R.C.) and Sri Lanka respectively. These agents, which belong to the general class of perylene quinonoid pigments, have a long history as traditional medicinal
D, Zhenjun, J W, Lown
openaire +2 more sources
Journal of Fungi, 2022 Melatonin (MLT), an evolutionarily conserved pleiotropic molecule, is implicated in numerous physiological processes in plants and animals. However, the effects of MLT on microbes have seldom been reported.
Wenjuan Wang +5 more
doaj +1 more source