Results 31 to 40 of about 1,024 (191)

GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma

Pharmacological Research, 2022
Lung adenocarcinoma (LUAD) is associated with poor prognosis. Identifying novel cancer targets and helpful therapeutic strategies remains a serious clinical challenge.
Xiaona Xie, Xueding Cai, Feng Zhou, Yaozhe Li, Qianzi Liu, Luqiong Cai, Wenjing Zhu, Jinqiu Wei, Chenying Jin, Zitian Liu, Chunhui Jiang, Haiyang Zhao, Lehe Yang, Chengguang Zhao, Xiaoying Huang   +14 more
doaj   +1 more source

Antimicrobial and Antileishmanial Activities of Hypocrellins A and B [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus , methicillin-resistant S. aureus ,
Guoyi, Ma, Shabana I, Khan, Melissa R, Jacob, Babu L, Tekwani, Zuqiang, Li, David S, Pasco, Larry A, Walker, Ikhlas A, Khan   +7 more
openaire   +2 more sources

Adaptive Responses to Oxidative Stress in the Filamentous Fungal Shiraia bambusicola

Molecules, 2016
Shiraia bambusicola can retain excellent physiological activity when challenged with maximal photo-activated hypocrellin, which causes cellular oxidative stress.
Huaxiang Deng, Jiajun Chen, Ruijie Gao, Xiangru Liao, Yujie Cai   +4 more
doaj   +1 more source

Response mechanism of hypocrellin colorants biosynthesis by Shiraia bambusicola to elicitor PB90

AMB Express, 2019
The valuable medicine Shiraia bambusicola P. Henn. and its major active substance hypocrellin exert unique curative effects on skin diseases, diabetes, and cancers. The wild S.
Wen Du, Chunlong Sun, Baogui Wang, Yanmei Wang, Bin Dong, Junhua Liu, Jiangbao Xia, Wenjun Xie, Jun Wang, Jingkuan Sun, Xuehong Liu, Hongguo Wang   +11 more
doaj   +1 more source

Nitric oxide regulates perylenequinones biosynthesis in Shiraia bambusicola S4201 induced by hydrogen peroxide

Scientific Reports, 2021
Shiraia bambusicola has been used as a traditional Chinese medicine for a long history. Its major medicinal active metabolites are perylenequinones, including hypocrellin A, elsinochrome A and so on. At present, the fermentation yield of perylenequinones
Ning Zhao, Yingying Yu, Yunxia Yue, Mingzhu Dou, Bingjing Guo, Shuzhen Yan, Shuanglin Chen   +6 more
doaj   +1 more source

Nitric oxide donor sodium nitroprusside-induced transcriptional changes and hypocrellin biosynthesis of Shiraia sp. S9

Microbial Cell Factories, 2021
Background Nitric oxide (NO) is a ubiquitous signaling mediator in various physiological processes. However, there are less reports concerning the effects of NO on fungal secondary metabolites.
Yan Jun Ma, Xin Ping Li, Yue Wang, Jian Wen Wang   +3 more
doaj   +1 more source

Schematic representation of hypocrellin biosynthesis pathway from glucose to hypocrellin.

, 2018
Schematic representation of hypocrellin biosynthesis pathway from glucose to hypocrellin.
Ye Zhao (39959), Huaxiang Deng (5167982), Zhengbing Guan (3095238), Xiaohui Zheng (305099), Zhecun Xu (5171552), Xiangru Liao (2047639), Yujie Cai (431517), Ruijie Gao (5167979)   +7 more
core   +1 more source

Enhanced hypocrellin production via coexpression of alpha-amylase and hemoglobin genes in Shiraia bambusicola

AMB Express, 2018
Shiraia bambusicola is an important and valuable macrofungus and hypocrellins are its main secondary metabolites which have been widely applied in many medical fields.
Ruijie Gao, Huaxiang Deng, Zhengbing Guan, Xiangru Liao, Yujie Cai   +4 more
doaj   +1 more source

Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study

Photodiagnosis and Photodynamic Therapy
Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment.
Muqiu Zhang, Xinyao Liu, Xin Ran, Runyan Gao, Jitong Sun, Kaiwen Zhuang, Zimeng You, Zhi Zhang, Yuping Ran   +8 more
doaj   +1 more source

Recent advances in theranostic agents based on natural products for photodynamic and sonodynamic therapy

View, 2020
The integration of diagnosis and therapy based on natural products has been receiving considerable attention in recent years because nature can contribute many fantastic functional molecules with good biocompatibility and low toxicity.
Jiasheng Wu, Jie Sha, Chuangli Zhang, Weimin Liu, Xiuli Zheng, Pengfei Wang   +5 more
doaj   +1 more source