Results 91 to 100 of about 922,924 (304)

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Chronic Central Adrenal Insufficiency in a Patient With Remote Traumatic Brain Injury and an Apparently Adequate Standard‐Dose ACTH Response: A Case Report

Clinical Case Reports
In patients with a remote history of traumatic brain injury, central adrenal insufficiency may remain unrecognized for decades. An apparently adequate response to standard‐dose ACTH stimulation should not preclude further evaluation of the hypothalamic ...
Kazunori Kageyama, Keisuke Sato, Satoshi Yamagata, Mizuki Tasso, Yuki Nakada, Shojiro Sawada   +5 more
doaj   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

Beyond BMI: Unsupervised Machine Learning Clustering of Bioelectrical Impedance Phenotypes Is Associated With Weight‐Recovery Trajectories in Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To identify data‐driven body composition phenotypes in patients with moderate‐to‐extreme anorexia nervosa (AN) using machine learning (ML) clustering of bioelectrical impedance analysis (BIA) parameters, and to test whether these phenotypes have specific psychopathological and childhood trauma profiles while correlating with early ...
Emanuele Cassioli, Gaia Maiolini, Eleonora D'Areglia, Livio Tarchi, Eleonora Rossi, Veronica Ceccarelli, Cristiano Dani, Luca Zompa, Chiara Ranieri, Enrico Lodovici, Anita Nannoni, Valdo Ricca, Giovanni Castellini   +12 more
wiley   +1 more source

Effectiveness of Artemisia pallens against behavioral depression and impact on monoaminergic and GABAergic systems

Bangladesh Journal of Pharmacology
Depression is characterized by decreased monoamine levels (dopamine, noradrenaline, serotonin), gamma-aminobutyric acid (GABA), elevated corticosterone, and dysregulation of the hypothalamic-pituitary-adrenal axis. This study aims to examine the effects
Deorao Madhaorao Awari, Rajendra O. Ganjiwale   +1 more
doaj   +1 more source

Machine learning‐based prediction of elevated N terminal pro brain natriuretic peptide among US general population

ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori, Shingo Fukuma, Kyohei Yamaji, Atsushi Mizuno, Naoki Kondo, Kosuke Inoue   +5 more
wiley   +1 more source

New directions for the treatment of adrenal insufficiency.

Frontiers in Endocrinology, 2015
Adrenal disease, whether primary, caused by defects in the hypothalamic-pituitary-adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of ...
Gerard eRuiz-Babot, Irene eHadjidemetriou, Peter James King, Leonardo eGuasti   +3 more
doaj   +1 more source

Community as Medicine: A Qualitative Exploration of Meaningful Social Support and Health for Trans‐ and Gender‐Diverse People in England

European Journal of Social Psychology, EarlyView.
ABSTRACT The poor mental and physical health of trans‐ and gender‐diverse (TGD) young people is well established and commonly attributed to gender minority stress. Although recent research has shown that social support can mitigate these effects, less attention has been paid to the psychological processes through which this occurs.
Chase Staras, Juliet Wakefield, Daragh McDermott, Bethany Jones   +3 more
wiley   +1 more source

Early life overfeeding and its effects on hypothalamic-pituitary-adrenal and sympatho-adrenal-medullary axes.

, 2017
Introduction: Overweight and obesity is becoming more and more common in Australia. The percentage of obesity in children has increased every year. Obese children in a particular are considered more likely to become obese in adulthood, which leads to a ...
Guohui Cai (5902259)
core   +1 more source

Peripheral inflammatory markers and metabolic profiles in temporal lobe epilepsy and functional dissociative seizures

Epileptic Disorders, EarlyView.
Abstract Background Temporal lobe epilepsy (TLE) and functional dissociative seizures (FDS) are distinct conditions that share overlapping clinical, neuropsychiatric, and biological features, including depressive symptoms, obesity‐related metabolic dysregulation, and alterations in systemic inflammatory markers.
Betül Merd, Şeyma Benli, Fatmanur Merd, Meltem Sönmez, Füsun Ferda Erdoğan   +4 more
wiley   +1 more source