Results 1 to 10 of about 140,789 (198)
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS ONE, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker +4 more
doaj +2 more sources
Andalas Obstetrics And Gynecology Journal, 2021 The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M.
David Perdana +2 more
openaire +2 more sources
Frontiers in Immunology, 2023 Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β cell.
Yangshun Tang +4 more
semanticscholar +1 more source
The Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and Immunology [PDF]
American Journal of Immunology, 2014 Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the
Bruno R.B. Pires +5 more
openaire +1 more source
Hypoxia inducible factor-1α is an important regulator of macrophage biology
Heliyon, 2023 Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate
Bingquan Qiu +5 more
semanticscholar +1 more source
Cells, 2021 Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin +10 more
doaj +1 more source
Biological Functions and Regulatory Mechanisms of Hypoxia-Inducible Factor-1α in Ischemic Stroke
Frontiers in Immunology, 2021 Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a major contributor to death or disability worldwide and has become a heavy societal and clinical burden.
Qianyan He +8 more
semanticscholar +1 more source
Hypoxia-Inducible Factor 1α Expression in Chorionic Tissue and Decidua of Women with Spontaneous Abortion at the First Trimester of Pregnancy [PDF]
American Journal of Biochemistry and Biotechnology, 2014 Oxygen-regulated genes expression has important role in pre-implantation embryonic metabolism regulation. Hypoxia Inducible Factor (HIF) regulated by hypoxia oxygen tension is crucial for placenta development. But the data about its role in spontaneous abortion is very poor. Thus, we aimed to determine an expression level of HIF-1I± in chorionic tissue
E. V. Mashkina +2 more
openaire +1 more source
MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models. [PDF]
PLoS ONE, 2015 Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its tight regulation is crucial in hypoxia related diseases such as cerebral ischemia.
Fu Jia Liu +6 more
doaj +1 more source
FEBS Open Bio, 2023 Hypoxia has been reported to be an important factor leading to male infertility, and it has been reported that hypoxia can induce the apoptosis of mouse spermatogenic cells.
Zixuan Wang +7 more
doaj +1 more source