Results 21 to 30 of about 140,789 (198)

Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

BMC Research Notes, 2011
The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α ...
Hagen Thilo, Chua Yee Liu
doaj   +1 more source

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization

Neural Regeneration Research, 2023
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization.
Yong Yu, Li-Kun Xia, Yu Di, Qing-Zhu Nie, Xiao-Long Chen   +4 more
doaj   +1 more source

Hypoxia inducible factor 1α, hypoxanthine‐guanine phosphoribolsyl transferase and NADPH oxidase 4 from northern elephant seals: cDNA characterization and tissue expression

The FASEB Journal, 2011
Northern elephant seals ( Mirounga angustirostris ) are naturally adapted to prolonged periods (1–3 months) of food deprivation (fasting) and tissue ischemia. Fasting elephant seal pups do not exhibit signs of oxidative damage or inflammation despite increases in the renin‐angiotensin system,
Jose Guadalupe Sonanez Organis, Jose Pablo Vazquez Medina, Andy Aguilar, Henry Forman, Daniel Crocker, Rudy Ortiz   +5 more
openaire   +1 more source

Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals

Tumor Biology, 2017
Hypoxia-inducible factor 1 is believed to play a prominent role in the survival and developing progress of cancers. As a result, inhibiting α subunit of hypoxia-inducible factor 1 represents an attractive strategy against tumor.
Ting Liu, Le Zhao, Huilian Hou, Lu Ding, Wei Chen, Xu Li   +5 more
doaj   +1 more source

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Ekspresi Hypoxia-Inducible Factor-1α menginduksi Ekspresi Eritropoietin Intraseluler, dan Vascular Endothelial Growth Factor pada Penderita Kanker Payudara dengan Anemia

Jurnal Kedokteran Brawijaya, 2013
 Anemia merupakan faktor prognostik independen untuk pertahanan hidup pasien kanker. Penurunan kapasitas oksigen pada darah dapat menyebabkan terjadinya kondisi hipoksia pada jaringan kanker . Hipoksia pada jaringan kanker dapat mengaktivasi faktor transkripsi hypoxia-inducible factor-1α (HIF-1α) yang kemudian akan mentranskripsi banyak gen lain ...
Muhammad Darwin P, Handono Kalim, Djoko Wahono S, Aru W Sudoyo, Fatchiyah Fatchiyah   +4 more
openaire   +2 more sources

Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells [PDF]

International Neurourology Journal, 2019
Purpose Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain.
Seung-Yeon Yoo, Ji-Young Yoo, Han-Byeol Kim, Tai-Kyoung Baik, Jun-Ho Lee, Ran-Sook Woo   +5 more
doaj   +1 more source

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Cells, 2020
Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy.
M. Alique, E. Sanchez-Lopez, G. Bodega, C. Giannarelli, J. Carracedo, R. Ramírez   +5 more
semanticscholar   +1 more source

Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia

Frontiers in Cell and Developmental Biology, 2021
The current study investigated the role of combination therapy with voacamine and vincristine in preventing mammary gland carcinoma through prolyl hydroxylase-2 activation.
Lakhveer Singh, Subhadeep Roy, Anurag Kumar, Shubham Rastogi, Dinesh Kumar, Mohd. Nazam Ansari, Abdulaziz S. Saeedan, Manjari Singh, Gaurav Kaithwas   +8 more
doaj   +1 more source

Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

Cancer Science, 2019
Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia has been known as a central hallmark of cancer cells and their microenvironment.
Y. Hayashi, A. Yokota, H. Harada, Gang Huang   +3 more
semanticscholar   +1 more source