Results 31 to 40 of about 140,789 (198)

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin.
L. Dunn, S. Kong, S. Tumanov, Weiyu Chen, J. Cantley, Anita Ayer, G. Maghzal, R. G. Midwinter, K. Chan, M. Ng, R. Stocker   +10 more
semanticscholar   +1 more source

Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia

Cells, 2022
The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analyze ...
Akram Hamidi, Alexandra Wolf, Rositsa Dueva, Melanie Kaufmann, Kirsten Göpelt, George Iliakis, Eric Metzen   +6 more
doaj   +1 more source

Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy

Scientific Reports, 2019
Previous studies have demonstrated intrarenal hypoxia in patients with diabetes. Hypoxia-inducible factor (HIF)-1 plays an important role in hypoxia-induced tubulointerstitial fibrosis.
Ryoichi Bessho, Y. Takiyama, Takao Takiyama, Hiroya Kitsunai, Yasutaka Takeda, Hidemitsu Sakagami, Tsuguhito Ota   +6 more
semanticscholar   +1 more source

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

Molecular Therapy: Nucleic Acids, 2021
Hypoxia induces a series of cellular adaptive responses that enable promotion of inflammation and cancer development. Hypoxia-inducible factor-1α (HIF-1α) is involved in the hypoxia response and cancer promotion, and it accumulates in hypoxia and is ...
Jianlong Wang, Xuyi Chen, Haijuan Hu, Mengting Yao, Yanbiao Song, Aimin Yang, Xiuhua Xu, Ning Zhang, Jianzhao Gao, Bin Liu   +9 more
doaj   +1 more source

Hypoxia Inducible Factor-1α: The Curator of Gut Homeostasis

Frontiers in Cellular and Infection Microbiology, 2020
The human gut microbiome is a stratified and resilient ecosystem co-inhabited by a diverse and dynamic pool of microorganisms. Microbial selection, establishment, and colonization are modulated through a complex molecular network of host-microbial ...
Tarun Kumar, R. Pandey, N. Chauhan
semanticscholar   +1 more source

Differential expression of hypoxia-inducible factor 1α in non-small cell lung cancer and small cell lung cancer

Clinics, 2012
OBJECTIVES: The aim of this study was to compare the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in small cell lung cancer and subtypes of non-small cell lung cancer and examine their relationships with ...
Eleni Karetsi, Maria G. Ioannou, Theodora Kerenidi, Markos Minas, Paschalis A. Molyvdas, Konstantinos I. Gourgoulianis, Efrosyni Paraskeva   +6 more
doaj   +1 more source

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

Nature Communications, 2018
Hypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in B lymphocytes are poorly defined.
Xianyi Meng, Bettina Grötsch, Yubin Luo, K. Knaup, M. Wiesener, Xiao-xiang Chen, J. Jantsch, S. Fillatreau, G. Schett, A. Bozec   +9 more
semanticscholar   +1 more source

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.

PLoS ONE, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α
Mahendran Botlagunta, Balaji Krishnamachary, Farhad Vesuna, Paul T Winnard, Guus M Bol, Arvind H Patel, Venu Raman   +6 more
doaj   +1 more source

Downregulation of Proline Hydroxylase 2 and Upregulation of Hypoxia-Inducible Factor 1α are Associated with Endometrial Cancer Aggressiveness.

Cancer management and research, 2019
Proline hydroxylase 2 (PHD2) is involved in tumorigenesis. This study aimed to examine PHD2 and hypoxia-inducible factor 1α (HIF-1α) expression in different endometrial tissues and explore the correlations between PHD2 and HIF-1α expression with clinicopathological characteristics of endometrial cancer.We collected 50 tissue sections of endometrial ...
Zhu,Chengcheng, Ding,Huafeng, Yang,Junwen, Zhou,Yihui, Luo,Yonghong, Shi,Suhua, Zhang,Ying, Wei,Yalan, Ni,Guantai   +8 more
openaire   +4 more sources

OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation

Cell Death and Disease, 2022
As a main regulator of cellular responses to hypoxia, the protein stability of hypoxia-inducible factor (HIF)-1α is strictly controlled by oxygen tension dependent of PHDs-catalyzed protein hydroxylation and pVHL complex-mediated proteasomal degradation.
Xing Liu, Hongyan Deng, Jinhua Tang, Zixuan Wang, Chunchun Zhu, Xiaolian Cai, Fangjing Rong, Xiaoyun Chen, Xueyi Sun, Shuke Jia, Gang Ouyang, Wenhua Li, Wuhan Xiao   +12 more
doaj   +1 more source