Results 1 to 10 of about 649,237 (386)

The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis [PDF]

Journal of Clinical Pathology, 2004
Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and ...
Greijer, A.E., Wall, E. van der
core   +9 more sources

Hypoxia-Inducible Factor 1 and Mitochondria: An Intimate Connection. [PDF]

Biomolecules, 2022
The general objective of the review is to explain the interaction between HIF-1 and mitochondria. On the one hand, this review describes the effects of HIF-1 on mitochondrial structure, including quantity, distribution, and morphology, as well as on mitochondrial metabolism and respiratory function.
Huang X, Zhao L, Peng R.
europepmc   +5 more sources

Expression of DDX3 Is Directly Modulated by Hypoxia Inducible Factor-1 Alpha in Breast Epithelial Cells [PDF]

PLoS ONE, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α
AG Angus, AM Owsianka, AO Noueiry, Arvind H. Patel, BA Teicher, Balaji Krishnamachary, BT Lahn, C Blancher, C Warnecke, CH Chao, CP Bracken, DJ Jamieson, DM Brizel, F Vesuna, Farhad Vesuna, GJ Dougherty, GL Semenza, GL Semenza, Guus M. Bol, H Tian, HJ Knowles, HM Sowter, J Niquet, K Polyak, M Botlagunta, M Ema, M Hockel, M Hu, M Schroder, M Schroder, M Sun, Mahendran Botlagunta, MM Matzuk, MS Wiesener, N Mamiya, O Cordin, O Johnstone, P Leroy, P Linder, P Vaupel, P Vaupel, Paul T. Winnard, PH Maxwell, PJ Kallio, R Gururajan, RH Wenger, RH Wenger, S Baranwal, S Hirohashi, S Lahiri, S Rocak, S. K. Batra, T Sekiguchi, TY Reynolds, Venu Raman, VS Yedavalli, X Guo, Y Ariumi, YZ Gu, ZB Han   +59 more
core   +7 more sources

Purification and Characterization of Hypoxia-inducible Factor 1 [PDF]

Journal of Biological Chemistry, 1995
Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment. HIF-1 DNA binding activity is also induced by hypoxia or cobalt in non-Epo-producing cells, suggesting a general role for HIF-1 in hypoxia signal transduction and ...
Guang L. Wang, Gregg L. Semenza
openaire   +3 more sources

Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth factor–C in locally advanced breast cancer patients [PDF]

Clinics, 2011
BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors.
Brito, Luiz Gustavo Oliveira, de Andrade, Jurandyr Moreira, Marana, Heitor Ricardo Cosiski, Peria, Fernanda Maris, Schiavon, Viviane Fernandes, Tiezzi, Daniel Guimarães   +5 more
core   +8 more sources

The Role of Hypoxia-inducible Factor-1 in Bladder Cancer. [PDF]

Curr Mol Med
Abstract: Bladder cancer (BC) is one of the most common malignant tumors worldwide and poses a significant hazard to human health. During the development of BC, hypoxia plays a crucial role. Hypoxia-inducible factor (HIF) is a key transcription factor for hypoxic adaptation, which regulates the transcription of various genes, including inflammation ...
Chai J, Yin S, Feng W, Zhang T, Ke C.
europepmc   +3 more sources

Hypoxia-inducible factor-1 and neuroglobin expression [PDF]

Neuroscience Letters, 2012
Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral ...
Lin Xie, Kunlin Jin, Kunlin Jin, Bryan Haines, David A. Greenberg, Xiao Mao, Judith Campisi, Marco Demaria   +7 more
openaire   +3 more sources

Interaction des virus avec la voie cellulaire de réponse à l’hypoxie [PDF]

, 2005
Des travaux récents réalisés in vitro montrent que l’appauvrissement du milieu de culture en oxygène (hypoxie) active la réplication du parvovirus humain B19, des virus du sarcome de Kaposi et de l’immunodéficience humaine, ainsi que l’expression de ...
Le Guyader, Nathalie, Pillet, Sylvie
core   +1 more source

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells [PDF]

, 2002
The incidence of distant metastases is higher in the tumours with low oxygen pressure than in those with high oxygen pressure. It is well known that hypoxia induces the transcription of various genes involved in angiogenesis and anaerobic metabolism ...
A Biroccio, A Raz, AL Kung, C Blancher, CV Dang, DM Brizel, DY Yoon, EK Rofstad, EK Rofstad, G Albrecht-Buehler, G Poste, GL Nicolson, GL Semenza, GL Wang, GL Wang, H Katoh, H Niizeki, H Watanabe, H Watanabe, H Watanabe, H Zhong, I Horiuchi, I Raijiman, IR Nabi, J Chen, J Wang, J-i Hamada, K Guillemin, KP Claffey, KP Claffey, LA Liotta, LA Liotta, LA Liotta, M Hockel, M Hosokawa, M Kobayashi, MW Halterman, N Akakura, N Akakura, P Seth, P Vaupel, Q Shi, R Malhotra, RA Gatenby, S Choi, Y Niinaka   +45 more
core   +2 more sources

Hypoxia-Inducible Factor 1

Chest, 1998
Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to hypoxia by activating the transcription of hundreds of target genes. The expression and activity of HIF-1 are oxygen-regulated, which provides a direct mechanism for transducing changes in cellular oxygenation to changes in gene expression.
Faton Agani, Bing-Hua Jiang, Narayan V. Iyer, Aimee Yu, Sandra W. Leung, Gregg L. Semenza, Charles M. Wiener   +6 more
openaire   +2 more sources