The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis [PDF]
Journal of clinical pathology, 2004 Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and ...
Greijer, A.E., Wall, E. van der
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Hypoxia-inducible factor-1 alpha expression in endometriosis: A retrospective observational case–control study of ovarian cyst capsules and endometrial tissue samples [PDF]
Journal of International Medical ResearchBackground This study aimed to compare the expression patterns of hypoxia-inducible factor-1α in ovarian cyst capsules and endometrial tissue samples from patients with and without endometriosis to evaluate its potential as a biomarker of hypoxia in ...
Ezgi Tolu Cenk +6 more
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Hypoxia-Inducible Factor 1 and Mitochondria: An Intimate Connection [PDF]
Biomolecules, 2022 The general objective of the review is to explain the interaction between HIF-1 and mitochondria. On the one hand, this review describes the effects of HIF-1 on mitochondrial structure, including quantity, distribution, and morphology, as well as on ...
Xiaochen Huang, Li Zhao, Ruiyun Peng
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Copper Regulation of Hypoxia-Inducible Factor-1 Activity [PDF]
Molecular Pharmacology, 2008 Previous studies have demonstrated that copper up-regulates hypoxia-inducible factor 1 (HIF-1). The present study was undertaken to test the hypothesis that copper is required for HIF-1 activation. Treatment of HepG2 cells with a copper chelator tetraethylenepentamine (TEPA) or short interfering RNA targeting copper chaperone for superoxide dismutase 1
Wenke Feng +4 more
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Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha [PDF]
, 2010 PURPOSE: Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumour progression. For the imaging of HIF-1-active tumours, we previously developed a protein, POS, which is effectively delivered to and selectively stabilized in HIF-1 ...
Hiraoka, Masahiro +10 more
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Journal of Pharmacological Sciences, 2011 The microenvironment of solid tumors is characterized by low pO2 that is well below physiological levels. Intratumoral hypoxia is a major factor contributing to cancer progression and is exacerbated as a result of oxygen consumption by rapidly ...
Shinae Kizaka-Kondoh +2 more
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Regulation of Metabolism by Hypoxia-Inducible Factor 1 [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2011 The maintenance of oxygen homeostasis is critical for survival, and the master regulator of this process in metazoan species is hypoxia-inducible factor 1 (HIF-1), which controls both O(2) delivery and utilization. Under conditions of reduced O(2) availability, HIF-1 activates the transcription of genes, whose protein products mediate a switch from ...
Gregg L. Semenza
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Retraction: Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling. [PDF]
J Biol ChemHirota K +6 more
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Statement of Retraction: Knockdown of hypoxia-inducible factor 1-alpha (HIF1α) interferes with angiopoietin-like protein 2 (ANGPTL2) to attenuate high glucose-triggered hypoxia/reoxygenation injury in cardiomyocytes. [PDF]
Bioengineeredeuropepmc +3 more sources
Cells, 2021 Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin +10 more
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