Results 21 to 30 of about 649,237 (386)
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS ONE, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker +4 more
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Biomedicines, 2020 Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the energy levels that are required to maintain biological functions.
Kiichi Hirota
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Research progress of HIF-1 mediated autophagy in cardiac diseases [PDF]
Jichu yixue yu linchuang, 2021 Hypoxia-inducible factor 1 (HIF-1) regulates the expression of target genes to keep the balance between oxygen supply and oxygen consumption, maintains oxygen homeostasis.
ZHANG Liu-jie, LI Jing, WU Bo
doaj
Proceedings of the National Academy of Sciences of the United States of America, 1995 Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
Guang-lei Wang +3 more
semanticscholar +1 more source
Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
BMC Research Notes, 2018 Objective Earlier studies from our group using hypoxia-inducible factor 3α knockout mice showed impairments in lung remodeling and lung endothelial cells.
Firman Zulkifli Amin +2 more
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Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. [PDF]
PLoS ONE, 2010 When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia Inducible Factors (HIFs) play a key role in this metabolic shift by regulating the transcription of ...
Nuria Pescador +12 more
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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.
Genes & Development, 1998 Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality.
N. Iyer +10 more
semanticscholar +1 more source
مجله دانشکده پزشکی اصفهان, 2019 Oxygen deficiency, referred to as hypoxia, can be divided into two categories of environmental (exogenous) which is sensitized by respiratory cells, and microenvironmental (endogenous) responses by other cells in the body, like cancer cells.
Fatemeh Choopani +4 more
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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.
Annual Review of Cell and Developmental Biology, 1999 Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS transcription factor consisting of HIF-1 alpha and HIF-1 beta subunits.
G. Semenza
semanticscholar +1 more source
Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]
, 2019 PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ +7 more
core +1 more source