Results 31 to 40 of about 649,237 (386)

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1*

Journal of Biological Chemistry, 1996
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor ...
G. Semenza, B. Jiang, S. Leung, R. Passantino, J. Concordet, P. Maire, A. Giallongo   +6 more
semanticscholar   +1 more source

Fifteen days of 3200m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle [PDF]

, 2016
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal ...
Bertrand, L, Bishop, David, D'Hulst, G, Deldique, L, Ferri, Alessandra, Francaux, M, Horman, S, Naslain, D   +7 more
core   +2 more sources

Hypoxia inducible factor 1 (HIF-1) and cardioprotection [PDF]

Acta Pharmacologica Sinica, 2010
Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH ...
Lei Xi, Ali Dursun, Dernet Tekin
openaire   +3 more sources

Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

Neural Regeneration Research, 2022
[INLINE:1] Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method ...
Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Ye   +8 more
doaj   +1 more source

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals

Tumor Biology, 2017
Hypoxia-inducible factor 1 is believed to play a prominent role in the survival and developing progress of cancers. As a result, inhibiting α subunit of hypoxia-inducible factor 1 represents an attractive strategy against tumor.
Ting Liu, Le Zhao, Huilian Hou, Lu Ding, Wei Chen, Xu Li   +5 more
doaj   +1 more source

Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells [PDF]

Kosin Medical Journal, 2019
Objectives Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several ...
Cho Eui Jin, Jung Hyun Lee, Geun Joo Kim, Tae Hwa Lee   +3 more
doaj   +1 more source

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

Haematologica, 2012
Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.
Maria Mastrogiannaki, Pavle Matak, Jacques R.R. Mathieu, Stéphanie Delga, Patrick Mayeux, Sophie Vaulont, Carole Peyssonnaux   +6 more
doaj   +1 more source

Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

Neural Regeneration Research, 2021
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao, Ya-Han Zhang, Hang Xue, Zi-Yi Wu, Chang Li, Ping Zhao   +5 more
doaj   +1 more source

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.

American Journal of Physiology, 1996
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix protein implicated in the transcriptional activation of genes encoding erythropoietin, glycolytic enzymes, and vascular endothelial growth factor in hypoxic mammalian cells.
B. Jiang, G. Semenza, C. Bauer, H. H. Marti   +3 more
semanticscholar   +1 more source