Results 41 to 50 of about 649,237 (386)

Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1α protein [PDF]

, 2004
Apigenin, a plant-derived flavone, is a potent inhibitor of cell proliferation and angiogenesis, but the mechanisms leading to the pathological anti-angiogenic effects of apigenin are still unclear.
Funae, Yoshihiko, Imaoka, Susumu, Osada, Mayuko   +2 more
core   +1 more source

Inhibition of HIF-1α through Suppression of NF-κB Activation by Compounds Isolated from Senecio graveolens [PDF]

, 2020
One of the characteristics of cancer is that the lack of oxygen in the cancer cells triggers changes in their gene expression. This hypoxia activates hypoxia-inducible factor 1-alpha and this in turn sets in motion the whole family of important ...
Apaza Ticona, Luis, Cano-Adamuz, Nuria, Rumbero Sánchez, Ángel   +2 more
core   +1 more source

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review

Biomedicines, 2021
Oxygen is essential for the maintenance of the body. Living organisms have evolved systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays an essential role in this process; it is a transcription factor that mediates ...
Kiichi Hirota
doaj   +1 more source

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells [PDF]

, 2009
Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and ...
Beyer-Mears, Castilla, Daub, Dery, Eady, Ferrara, Formica, Gilbert, Gong, Hains, Hanneken, Hertog, Hertog, Hollman, Jacques, Jeon, Jeong, Jeremy D. Rhodes, Julie Sanderson, Kampkotter, Klein, Klein, Knekt, Knekt, Lamson, Leopoldini, Leung, Li, Lija, Listgarten, Livak, Maiese, Manach, Park, Paul A. Kroon, Pauline Radreau, Reddan, Rice-Evans, Richard F. Mithen, Ridley, Sanderson, Sanderson, Schofield, Semenza, Semenza, Semenza, Shui, Shui, Shui, Spector, Tavani, Taylor, Triantafyllou, Triantafyllou, Truscott, Vandesompele, Wang, Wilson, Wormstone   +58 more
core   +1 more source

The role of hypoxia-inducible factor 1 in atherosclerosis: Figure 1 [PDF]

Journal of Clinical Pathology, 2012
Atherosclerosis is by far the most frequent underlying cause of coronary artery disease, carotid artery disease and peripheral arterial disease, and is associated with high morbidity and mortality. Hypoxic areas are known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages,
Qian Chen, Linggen Gao, Li Fan, Xianliang Zhou   +3 more
openaire   +3 more sources

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Icariin activates far upstream element binding protein 1 to regulate hypoxia-inducible factor-1α and hypoxia-inducible factor-2α signaling and benefits chondrocytes [PDF]

PeerJ, 2023
Icariin (ICA) is a typical flavonoid glycoside derived from epimedium plants. It has both anabolic and anti-catabolic effects to improve bone mineral density and reduce bone microstructural degradation. However, the effect and underlying mechanism of ICA
Pengzhen Wang, Pingping Zhu, Shaoheng Zhang, Wei Yuan, Zhihe Liu   +4 more
doaj   +2 more sources

Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia [PDF]

, 2010
Hundreds of genes can be regulated by hypoxia-inducible factor 1 (HIF1) under hypoxia. Here we demonstrated a HIF1-mediated induction of protein phosphatase 1, regulatory subunit 3C gene (PPP1R3C) in human MCF7 cells under hypoxia.
Liu, Xiao-Ling, Shen, Guo-Min, Zhang, Feng-Lin, Zhang, Jun-Wu   +3 more
core   +1 more source

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

Haematologica, 2010
Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis.
Sally K. Martin, Peter Diamond, Sharon A. Williams, Luen Bik To, Daniel J. Peet, Nobutaka Fujii, Stan Gronthos, Adrian L. Harris, Andrew C.W. Zannettino   +8 more
doaj   +1 more source

Hypoxia‐inducible factor 1 and cancer pathogenesis [PDF]

IUBMB Life, 2008
AbstractHypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increase O2 availability by stimulating angiogenesis or that ...
openaire   +3 more sources