Results 41 to 50 of about 678,452 (368)

Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase [PDF]

, 2015
There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1.
Nishimura, Ryo, Okuda, Kiyoshi
core   +1 more source

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review

Biomedicines, 2021
Oxygen is essential for the maintenance of the body. Living organisms have evolved systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays an essential role in this process; it is a transcription factor that mediates ...
Kiichi Hirota
doaj   +1 more source

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J., Gomez-Roman, Natividad, McGregor, Fiona, Plumb, Jane   +3 more
core   +1 more source

Hypoxia-Inducible Factor 1

Chest, 1998
Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to hypoxia by activating the transcription of hundreds of target genes. The expression and activity of HIF-1 are oxygen-regulated, which provides a direct mechanism for transducing changes in cellular oxygenation to changes in gene expression.
Gregg L. Semenza, Faton Agani, Narayan Iyer, Bing-Hua Jiang, Sandra Leung, Charles Wiener, Aimee Yu   +6 more
openaire   +1 more source

Icariin activates far upstream element binding protein 1 to regulate hypoxia-inducible factor-1α and hypoxia-inducible factor-2α signaling and benefits chondrocytes [PDF]

PeerJ, 2023
Icariin (ICA) is a typical flavonoid glycoside derived from epimedium plants. It has both anabolic and anti-catabolic effects to improve bone mineral density and reduce bone microstructural degradation. However, the effect and underlying mechanism of ICA
Pengzhen Wang, Pingping Zhu, Shaoheng Zhang, Wei Yuan, Zhihe Liu   +4 more
doaj   +2 more sources

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]

, 2014
Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam, Coughlan, Karen, Gibbs, Bernhard F., Lall, Gurprit S., Lall, Harjinder S., Sumbayev, Vadim V.   +5 more
core   +1 more source

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

Haematologica, 2010
Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis.
Sally K. Martin, Peter Diamond, Sharon A. Williams, Luen Bik To, Daniel J. Peet, Nobutaka Fujii, Stan Gronthos, Adrian L. Harris, Andrew C.W. Zannettino   +8 more
doaj   +1 more source

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells [PDF]

, 2009
Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and ...
Beyer-Mears, Castilla, Daub, Dery, Eady, Ferrara, Formica, Gilbert, Gong, Hains, Hanneken, Hertog, Hertog, Hollman, Jacques, Jeon, Jeong, Jeremy D. Rhodes, Julie Sanderson, Kampkotter, Klein, Klein, Knekt, Knekt, Lamson, Leopoldini, Leung, Li, Lija, Listgarten, Livak, Maiese, Manach, Park, Paul A. Kroon, Pauline Radreau, Reddan, Rice-Evans, Richard F. Mithen, Ridley, Sanderson, Sanderson, Schofield, Semenza, Semenza, Semenza, Shui, Shui, Shui, Spector, Tavani, Taylor, Triantafyllou, Triantafyllou, Truscott, Vandesompele, Wang, Wilson, Wormstone   +58 more
core   +1 more source

Hypoxia and tissue destruction in pulmonary TB. [PDF]

, 2016
BACKGROUND: It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as ...
Aigbirhio, Franklin, Al-Nahhas, Adil, Belton, Moerida, Brilha, Sara, Dembek, Marcin, Elkington, Paul T, Friedland, Jon S, Fryer, Tim D, Green, Justin, Hong, Young T, Manavaki, Roido, Mauri, Francesco, Moores, Rachel, Nijran, Kuldip, Patel, Neva H, Tezera, Liku   +15 more
core   +6 more sources