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Exenatide Is Neuroprotective in a New Rabbit Model of Hypoxia-Ischemia [PDF]

Cells
Hypoxia-ischemia is a serious perinatal complication affecting neonates globally. Animal models have increased the understanding of its pathophysiology and have been used to investigate potential therapies. Exenatide, clinically used for the treatment of
Eridan Rocha-Ferreira, Malin Carlsson, Pernilla Svedin, Kerstin Ebefors, Owen Herrock, Anna-Lena Leverin, Henrik Hagberg   +6 more
doaj   +2 more sources

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study [PDF]

Frontiers in Aging Neuroscience
BackgroundTraumatic brain injury (TBI) can generally be divided into focal damage and diffuse damage, and neonate Hypoxia-Ischemia Brain Damage (nHIBD) is one of the causes of diffuse damage.
Shengjie Zhang, Ruqiu Zhang, Zhaoqin Chen, Zihan Shao, An Li, Fan Li, Fang Huang   +6 more
doaj   +2 more sources

MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia [PDF]

Cells
Brain damage caused by hypoxia-ischemia is a serious complication for a newborn with possible life-long sequelae. To develop targeted neuroprotective strategies, it is essential to understand the mechanisms of injury, particularly the role of microglial ...
Andrea Jonsdotter, Henrik Hagberg, Anna-Lena Leverin, Joakim Ek, Kerstin Ebefors, Eridan Rocha-Ferreira, Ylva Carlsson   +6 more
doaj   +2 more sources

Modulating mitochondrial metabolism: a neuroprotective mechanism for hypoxic–ischemic preconditioning [PDF]

Cell Regeneration
Hypoxia–ischemia plays a role in the physiological and pathological processes of various diseases and presents a common challenge for humans under extreme environmental conditions.
Wenxin Li, Guo Shao, Ruifang Qi
doaj   +2 more sources

Repurposed Edaravone, Metformin, and Perampanel as a Potential Treatment for Hypoxia–Ischemia Encephalopathy: An In Vitro Study

Biomedicines, 2022
Hypoxia–ischemia encephalopathy results from the interruption of oxygen delivery and blood flow to the brain. In the developing brain, it can lead to a brain injury, which is associated with high mortality rates and comorbidities.
Daniela Silva, Ruben Rocha, Ana Salomé Correia, Bárbara Mota, Maria Dulce Madeira, Nuno Vale, Armando Cardoso   +6 more
doaj   +1 more source

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]

, 2015
c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan, Li, Jinhui, Li, Xihong, Mu, Dezhi, Qu, Yi, Tang, Jun, Wu, Jinlin, Xiong, Tao, Zhang, Li   +8 more
core   +9 more sources

Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels

Redox Biology, 2020
Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (
Jeannette Vasquez-Vivar, Zhongjie Shi, Jeong-Won Jeong, Kehuan Luo, Amit Sharma, Karthikeyan Thirugnanam, Sidhartha Tan   +6 more
doaj   +1 more source

Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury

Fluids and Barriers of the CNS, 2021
Background Neonatal encephalopathy often leads to lifelong disabilities with limited treatments currently available. The brain vasculature is an important factor in many neonatal neurological disorders but there is a lack of diagnostic tools to evaluate ...
E. Axel Andersson, Carina Mallard, C. Joakim Ek   +2 more
doaj   +1 more source

Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic–Ischemic Brain Injury in Neonatal Mice

ASN Neuro, 2023
A clinical challenge remains in the treatment of hypoxic–ischemic brain injury in newborns. Nicotinamide adenine dinucleotide (NAD + ) has beneficial effects in animal models of adult stroke.
Takuya Kawamura, Gagandeep Singh Mallah, Maryam Ardalan, Tetyana Chumak, Pernilla Svedin, Lina Jonsson, Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Tomoaki Ikeda, Henrik Hagberg, Mats Sandberg, Carina Mallard   +11 more
doaj   +1 more source

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury

Molecules, 2018
Neonatal hypoxia–ischemia is one of the main causes of mortality and disability of newborns. To study the mechanisms of neonatal brain cell damage, we used a model of neonatal hypoxia–ischemia in seven-day-old rats, by annealing of the common
Denis N. Silachev, Egor Y. Plotnikov, Irina B. Pevzner, Ljubava D. Zorova, Anastasia V. Balakireva, Mikhail V. Gulyaev, Yury A. Pirogov, Vladimir P. Skulachev, Dmitry B. Zorov   +8 more
doaj   +1 more source