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Hypoxia-ischemia and thiamine deficiency.
Clinical neuropathology, 1993In order to test the hypothesis that Wernicke's encephalopathy is of topographic rather than of pathogenetic specificity we examined the brains of 49 patients without any evidence of chronic alcoholism. They had died at least four days after an event of severe hypoxia-ischemia.
A O, Vortmeyer, C, Hagel, R, Laas
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Responses of the SVZ to Hypoxia and Hypoxia/Ischemia
2006Stroke is a devastating injury caused by interruption of the blood supply to the brain. Each year, about 700,000 people in the United States suffer a stroke incurring healthcare costs of more than $50 billion (Heart Disease and Stroke Statistics 2003 Update, 2002). While advances in the acute treatment of stroke have improved the survival rates, little
Ryan J. Felling +3 more
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Cerebral hypoxia-ischemia in immature rats: Methodological considerations
Experimental Neurology, 1988We used a model of perinatal hypoxic/ischemic brain damage which combines unilateral common carotid artery ligation and hypoxia (8% O2). Protein synthesis inhibition and cell loss were found in the ipsilateral forebrain of 11-day-old rats when hypoxia was initiated 4 h but not 24 h after carotid ligation. [14C]Iodoantipyrine uptake studies suggest that
B E, Dwyer +2 more
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Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia
2009Matrix metalloproteinase enzymes (MMPs) have been implicated in the pathogenesis of cerebral ischemia (stroke) and neurodegenerative diseases. Until recently, however, the mechanism of activation of MMPs in these disorders remained unclear. Following a hypoxic-ischemic insult, we identified a novel posttranslational modification (PTM) of MMPs involving
Zezong Gu, Jiankun Cui, Stuart A. Lipton
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Metabolic Aspects of Cerebral Hypoxia-Ischemia
1977This communication, which is focused on changes in brain metabolism in hypoxia and ischemia, briefly summarizes results obtained in this and other laboratories during the last 4–5 years. An attempt will be made to describe the characteristic features of hypoxic hypoxia, both at normal and at reduced perfusion pressures, as well as of incomplete and ...
B. K. Siesjö +2 more
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The biology and pathology of hypoxia-ischemia: an update.
Archivum immunologiae et therapiae experimentalis, 2005After an hypoxic-ischemic (HI) insult, a multi-faceted complex cascade of events occurs that ultimately causes cell death and neurological damage to the central nervous system. The various cascades include, amongst others: immunological changes, such as the activation of the complement system and the generation of antibodies; increased inflammation ...
Andrew N, Clarkson +2 more
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Perinatal Hypoxia-Ischemia and Brain Injury
Pediatric Research, 2000Edwards, A. D., Azzopardi, D. V.
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[Molecular factors of cerebral hypoxia-ischemia].
Revista de neurologia, 1996In recent years much has been learned about the cellular and molecular events underlying cerebral hypoxia-ischemia (HI). We review, from a molecular standpoint, the main pathogenetic theories in hypoxic-ischemic cerebral injury, including excitotoxicity, free radical damage, and the role of growth factors, proto-oncogenes and heat shock proteins.
A, Macaya +3 more
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[Cell death in neonatal hypoxia-ischemia].
Revista de neurologia, 2000To review the mechanisms of cell death (CD) in the developing brain after hypoxia-ischemia (HI).The possibility of limiting the CD which occurs in serious situations of cerebral HI is based on advances in the understanding of the underlying cellular and molecular mechanisms. Various experimental models offer the opportunity to study these mechanisms in
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