Roles of nitric oxide in brain hypoxia-ischemia
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999 A large body of evidence has appeared over the last 6 years suggesting that nitric oxide biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia-ischemia. Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective ...
Bolaños, Juan P, Almeida, Angeles
openaire +2 more sources
Treatment with docosahexaenoic acid after hypoxia-ischemia improves forepaw placing in a rat model of perinatal hypoxia-ischemia [PDF]
American Journal of Obstetrics and Gynecology, 2010 Docosahexaenoic acid (DHA) is a dietary fatty acid with neuroprotective properties. We hypothesized that DHA treatment after hypoxia-ischemia would improve function and reduce brain volume loss in a perinatal rat model.Seven-day-old Wistar rat pups from 7 litters (n = 84) underwent right carotid ligation, followed by 8% O(2) for 90 minutes.
Deborah R, Berman +3 more
openaire +2 more sources
Induce Stroke via Hypoxia-Ischemia v2 [PDF]
, 2019 Summary: This document describes the procedure for inducing a stroke in diabetic RCS10 mice, their non-diabetic controls and NON/ShiLtJ control mice. Our initial objective was to use those RCS10 mice that did not become diabetic as the controls for the experiment to compare the effect of diabetes on stroke outcome and that data is illustrated in ...
openaire +1 more source
Reduction of cytochrome C oxidase during vasovagal hypoxia-ischemia in human adult brain: a case study [PDF]
, 2013 Near-infrared spectroscopy (NIRS)-derived measurement of oxidized cytochrome c oxidase concentration ([oxCCO]) has been used as an assessment of the adequacy of cerebral oxygen delivery.
A Duncan +9 more
core +2 more sources
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
core +2 more sources
Cardiac arrest-induced global brain hypoxia-ischemia during development affects spontaneous activity organization in rat sensory and motor thalamocortical circuits during adulthood [PDF]
, 2016 Normal maturation of sensory information processing in the cortex requires patterned synaptic activity during developmentally regulated critical periods.
Middleton, Jason W, Shoykhet, Michael
core +2 more sources
Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia [PDF]
, 2018 Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment.
Bellini, Maria Jose +3 more
core +2 more sources
Mouse renal 4T1 cell engraftment as a model to study the influence of hypoxia in breast cancer progression [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To develop a mouse model to study the influence of hypoxia in breast cancer progression and metastasis. METHODS: The 4T1 cell line was used to engraft the kidneys of female BALB/c mice.
Heriton Marcelo Ribeiro Antonio +5 more
doaj +2 more sources
Animal Models and Experimental Medicine, 2020 Background Zebrafish models for neurovascular diseases offer new methods for elucidation of molecular pathways to tissue damage. External fertilization and high fecundity provide opportunities for transgenics and other forms of genetic manipulation that ...
Kaitlyn M. Marino +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2004 This experiment was designed to test the hypothesis that endogenous corticotropin-releasing factor (CRF) contributes to the neurodegenerative process following an ischemic insult.
Yoshifumi Kagamiishi +2 more
doaj +1 more source