General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]
PLoS ONE, 2014 Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Hui Wang, Daniel P Raleigh
doaj +13 more sources
A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models
Nature Communications, 2023 In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose.
, Heather C Denroche, Julien Thevenet
exaly +2 more sources
Effect of Copper-Catalyzed Oxidation on the Aggregation of the Islet Amyloid Polypeptide [PDF]
AntioxidantsThe islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone secreted by pancreatic β-cells that is known to aggregate into amyloid fibrils. These fibrils accumulate in the pancreatic islets of individuals afflicted with type 2 diabetes and are ...
Océane Amilca +4 more
doaj +2 more sources
Fatty acids alter to the toxicity of islet amyloid polypeptide aggregates in a length and saturation dependent manner [PDF]
iScienceSummary: Abrupt the aggregation of islet amyloid polypeptide (IAPP), a 37 amino acid hormone, is an expected molecular cause of type 2 diabetes (T2D), a severe pathology that affects more than 30 million Americans.
Jadon Sitton +4 more
doaj +2 more sources
The role of amylin, a gut–brain axis hormone, in metabolic and neurological disorders [PDF]
FASEB BioAdvancesAmylin, also known as islet amyloid polypeptide (IAPP), is a pancreatic β‐cell peptide hormone involved in satiation and control food intake. It is also produced in smaller quantities by neurons, the gastrointestinal tract, and spinal ganglia.
Tahir Muhammad +4 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2022 The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of ...
Lucie Khemtemourian +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived ...
Tatyana Gurlo +8 more
doaj +1 more source
Islet amyloid polypeptide does not suppress pancreatic cancer
Molecular Metabolism, 2023 Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression.
Austin J. Taylor +7 more
doaj +1 more source
Studies on alpha-synuclein and islet amyloid polypeptide interaction
Frontiers in Molecular Biosciences, 2023 Introduction: Parkinson’s disease and type 2 diabetes have both elements of local amyloid depositions in their pathogenesis. In Parkinson’s disease, alpha-synuclein (aSyn) forms insoluble Lewy bodies and Lewy neurites in brain neurons, and in type 2 ...
Ye Wang +5 more
doaj +1 more source
High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus. [PDF]
PLoS ONE, 2014 Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid ...
Johan F Paulsson +10 more
doaj +1 more source