Results 11 to 20 of about 20,996 (180)
Structural and morphological dynamics of "on-path" and "off-path" oligomers of human islet amyloid polypeptide. [PDF]
Protein SciAbstract The deposition of cytotoxic human islet amyloid polypeptide (IAPP) aggregates is a hallmark feature of Type 2 Diabetes. However, the structural evolution and cytotoxicity of IAPP aggregate species remain poorly understood. This study combines kinetics, biophysical and cell assays to resolve the morphological dynamics of IAPP aggregation. Using
Warren D, Sitton J, Kurouski D.
europepmc +2 more sources
Interventionist Aid and the War in Ukraine [PDF]
The Review of International Affairs, 2023 Aid Policies In The First Year Of The War In Ukraine Constitute A Unique And Unprecedented Historical Case Destined To Leave An “Echo” In The International System Far Beyond Those Of The Individual Ukrainian Case And The Aid Sector Alone. Using A Realist
Igor Pellicciari
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Frontiers in Molecular Biosciences, 2022 The cytotoxic self-aggregation of β-amyloid (Aβ) peptide and islet amyloid polypeptide (IAPP) is implicated in the pathogenesis of Alzheimer’s disease (AD) and Type 2 diabetes (T2D), respectively. Increasing evidence, particularly the co-deposition of Aβ
Kenana Al Adem +12 more
doaj +1 more source
Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide. [PDF]
PLoS ONE, 2011 Assembly of amyloid-beta peptide (Aβ) into cytotoxic oligomeric and fibrillar aggregates is believed to be a major pathologic event in Alzheimer's disease (AD) and interfering with Aβ aggregation is an important strategy in the development of novel ...
Nasrollah Rezaei-Ghaleh +4 more
doaj +1 more source
Molecular Neurodegeneration, 2022 Background The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive.
Guoxin Zhang +6 more
doaj +1 more source
Clinical and Experimental Hypertension, 2022 Background The relationship between pulse pressure and prognosis in patients with chronic coronary syndrome (CCS) is contradictory. In the present study, we aimed to examine the relationship between intra-aortic pulse pressure (IAPP) and major adverse ...
Halil Aktas, Murat Gul
doaj +1 more source
The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide
Frontiers in Molecular Biosciences, 2021 Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation.
Mikkel Christensen +5 more
doaj +1 more source
Facet-dependent interactions of islet amyloid polypeptide with gold nanoparticles: Implications for fibril formation and peptide-induced lipid membrane disruption [PDF]
, 2017 A comprehensive understanding of the mechanisms of interaction between proteins or peptides and nanomaterials is crucial for the development of nanomaterial-based diagnostics and therapeutics.
Alison A. Edwards +14 more
core +8 more sources
Laser-induced periodic surface structures as optical resonators for organic thin-film distributed feedback lasers [PDF]
EPJ Web of Conferences, 2023 Laser-induced periodic surface structures (LIPSS) have received considerable attention due to their potential for micro-and nanostructuring and surface functionalization of various materials.
Dong Tiange +5 more
doaj +1 more source
Biomolecules, 2023 (1) Background and aims: Amyloidosis due to aggregation of amyloid-β (Aβ42) is a key pathogenic event in Alzheimer’s disease (AD), whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islets leads to β-cell dysfunction.
Qing-Rong Liu +5 more
doaj +1 more source