Results 21 to 30 of about 20,996 (180)
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]
, 2010 ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E +7 more
core +2 more sources
Frontiers in Microbiology, 2020 Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes.
Ana F. Raimundo +11 more
doaj +1 more source
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. [PDF]
PLoS ONE, 2016 Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis.
Ingrid C Rulifson +16 more
doaj +1 more source
Food Science and Human Wellness, 2021 Islet amyloid polypeptide (IAPP), or amylin, has been identified as a key factor in the development of type 2 diabetes (T2D). IAPP aggregates, which form amyloid fibrils, contribute to cytotoxicity of the pancreatic β-cells, resulting in loss of function
Raliat O. Abioye, Chibuike C. Udenigwe
doaj +1 more source
Global Sensitivity Methods for Design of Experiments in Lithium-ion Battery Context [PDF]
, 2020 Battery management systems may rely on mathematical models to provide higher performance than standard charging protocols. Electrochemical models allow us to capture the phenomena occurring inside a lithium-ion cell and therefore, could be the best model
Pozzi, Andrea +3 more
core +2 more sources
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates
Frontiers in Molecular Biosciences, 2021 The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is resolved in terms of the ...
Diana C. Rodriguez Camargo +18 more
doaj +1 more source
Experimental models for investigating IAPP regulation of food intake in rats and mice [PDF]
, 2012 Background: Maintenance of energy balance is one of the fundamental processes of living organisms and involves complex regulatory pathways. Appetite regulation is an important component of this, because it modulates energy intake.
Olsson, Madelene
core +1 more source
Molecular Brain, 2023 The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain.
Cristina Nuñez-Diaz +6 more
doaj +1 more source
Stochastic Representations of Ion Channel Kinetics and Exact Stochastic Simulation of Neuronal Dynamics [PDF]
, 2014 In this paper we provide two representations for stochastic ion channel kinetics, and compare the performance of exact simulation with a commonly used numerical approximation strategy.
Anderson, David F. +2 more
core +3 more sources
陆军军医大学学报, 2023 Objective To investigate the effects of intraperitoneal injection of islet amyloid polypeptide (IAPP) on the expression profiles of circular RNAs (circRNAs) and messenger RNAs (mRNAs) in the brain tissue of Alzheimer's disease (AD) mice and wild-type ...
HOU Mingliang +3 more
doaj +1 more source