Results 41 to 50 of about 20,996 (180)

Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation

Biomolecules, 2021
Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM).
Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson   +7 more
doaj   +1 more source

Characterizing mixed mode oscillations shaped by noise and bifurcation structure

, 2010
Many neuronal systems and models display a certain class of mixed mode oscillations (MMOs) consisting of periods of small amplitude oscillations interspersed with spikes.
Juan Luis Cabrera, Peter Borowski, Press W., Rachel Kuske, Tucker A. B., White J. A., Yue-Xian Li   +6 more
core   +1 more source

Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease.

PLoS ONE, 2019
The biologically active pancreatic hormone peptide islet amyloid polypeptide (IAPP) regulates brain functions such as appetite and cognition. It also plays a role in clearance of amyloid beta (Aβ), a peptide implicated in the dementia disorder Alzheimer ...
Nina Schultz, Shorena Janelidze, Elin Byman, Lennart Minthon, Katarina Nägga, Oskar Hansson, Malin Wennström   +6 more
doaj   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity

Scientific Reports, 2017
Aggregation of islet amyloid polypeptide (IAPP), a peptide hormone co-synthesized and co-stored with insulin in pancreatic cells and also co-secreted to the circulation, is associated with beta-cell death in type-2 diabetes (T2D). In T2D patients IAPP is
Emily H. Pilkington, Yanting Xing, Bo Wang, Aleksandr Kakinen, Miaoyi Wang, Thomas P. Davis, Feng Ding, Pu Chun Ke   +7 more
doaj   +1 more source

Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity

Frontiers in Molecular Biosciences, 2022
The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes.
Mathilde Fortier, Mathilde Fortier, Mélanie Côté-Cyr, Mélanie Côté-Cyr, Vy Nguyen, Vy Nguyen, Margaryta Babych, Margaryta Babych, Phuong Trang Nguyen, Phuong Trang Nguyen, Roger Gaudreault, Roger Gaudreault, Steve Bourgault, Steve Bourgault   +13 more
doaj   +1 more source

A Virtual Element Method for a Nonlocal FitzHugh-Nagumo Model of Cardiac Electrophysiology

, 2018
We present a Virtual Element Method (VEM) for a nonlocal reaction-diffusion system of the cardiac electric field. To this system, we analyze an $H^1(\Omega)$-conforming discretization by means of VEM which can make use of general polygonal meshes.
Anaya, Verónica, Bendahmane, Mostafa, Mora, David, Sepúlveda, Mauricio   +3 more
core   +3 more sources

Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide [PDF]

, 2016
Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in ...
Hawkins, N, Hodder, P, Jean, L, Lee, CF, Vaux, DJ   +4 more
core   +1 more source

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease: two triggers, one disease

Neural Regeneration Research, 2021
Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent ...
Sofia Ferreira, Ana F Raimundo, Regina Menezes, Ivo C Martins   +3 more
doaj   +1 more source