Results 61 to 70 of about 20,996 (180)
Public Participation in New Local Governance Spaces: The Case for Community Development in Local Strategic Partnerships [PDF]
, 2014 Research into public participation in local decision-making has increased over the past forty years, reflecting increased interest in the subject from academic, policy and practitioner perspectives.
Purcell, Martin
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT A key challenge for the genetic improvement of canola (Brassica napus), one of the world's most important oilseeds, is the limited natural variation for commercially important traits. The creation of new variation is hindered by the lack of functional knowledge about genes controlling these traits.
Morgan W. Kirzinger +30 more
wiley +1 more source
Transient spatiotemporal chaos collapses into periodic and steady states in an electrically-coupled neural ring network [PDF]
, 2012 Chaotic behavior in a spatially extended system is often referred to as spatiotemporal chaos. The trajectories of a system as it evolves through state space are described by irregular spatial and temporal patterns.
Keplinger, Keegan
core
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
Integer Discontinuity of Density Functional Theory
, 2014 Density functional approximations to the exchange-correlation energy of Kohn-Sham theory, such as the local density approximation and generalized gradient approximations, lack the well-known integer discontinuity, a feature that is critical to describe ...
Mosquera, Martin A., Wasserman, Adam
core +1 more source
Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells [PDF]
, 2019 The intracellular life of insulin secretory granules (ISGs) from biogenesis to secretion depends on their structural (e.g. size) and dynamic (e.g. diffusivity, mode of motion) properties.
Bugliani, Marco +9 more
core +3 more sources
On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides
Journal of Diabetes Research, 2015 Pancreatic islets in type 2 diabetes mellitus (T2DM) patients are characterized by reduced β-cells mass and diffuse extracellular amyloidosis.
Marianna Flora Tomasello +2 more
doaj +1 more source
eLife, 2016 Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP ...
Andisheh Abedini +15 more
doaj +1 more source
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. [PDF]
PLoS ONE, 2013 Type 2 diabetes (T2D) is a complex disease characterized by beta cell dysfunctions. Islet amyloid polypeptide (IAPP) is highly conserved and co-secreted with insulin with over 40% of autopsy cases of T2D showing islet amyloid formation due to IAPP ...
Vincent Kwok Lim Lam +26 more
doaj +1 more source
Protein Science, Volume 35, Issue 4, April 2026.Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova +2 more
wiley +1 more source