Results 81 to 90 of about 20,996 (180)

Cell-to-cell transmission of IAPP aggregates in T2DM induces neuronal death by triggering oxidative stress and ferroptosis

Neurobiology of Disease
Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of neurodegenerative diseases, yet the underlying mechanisms remain elusive. A hallmark feature of T2DM is the amyloid deposition of islet amyloid polypeptide (IAPP) in the pancreas ...
Honglin Zheng, Yapei Yuan, Na Zhang, Hang Zhang, Suying Duan, Chenyang Liu, Yaochong Zhang, Qiang Li, Han Liu, Mibo Tang, Haiyang Luo, Yuming Xu   +11 more
doaj   +1 more source

The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. [PDF]

PLoS ONE, 2015
Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP).
Hanjun Guan, K Martin Chow, Eunsuk Song, Nirmal Verma, Florin Despa, Louis B Hersh   +5 more
doaj   +1 more source

Synergistic SnSe2@Ti3C2Tx MXene Heterostructured Separator for Highly Efficient Polysulfide Adsorption, Catalytic Redox Acceleration, and Enhanced Electrochemical Stability in Advanced Lithium–Sulfur Batteries

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 2, March 2026.
A multifunctional SnSe2@MXene heterostructure coated on a separator serves as a catalytic interlayer in Li‐S batteries. This design synergistically integrates the strong polysulfide adsorption and catalytic activity of SnSe2 with the high electrical conductivity of the MXene matrix, effectively suppressing the shuttle effect and enabling long‐term ...
Amirhossein Mirtaleb, Matija Scekic, Ruigang Wang   +2 more
wiley   +1 more source

A modeling framework for contact, adhesion and mechano-transduction between excitable deformable cells

, 2017
Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation of electric signals and chemical quantities through them is responsible for their nonlinear contraction and dilatation. In this study, a theoretical model and a finite
Gizzi, Alessio, Lenarda, Pietro, Paggi, Marco   +2 more
core   +1 more source

Preclinical advances in antibodies against N‐terminal Aβ4‐x species for Alzheimer's disease and cerebral amyloid angiopathy

Ibrain, Volume 12, Issue 1, Page 52-64, Spring 2026.
This review provides an update on monoclonal and polyclonal antibodies developed to specifically target amyloid beta (Aβ) truncated species starting at residue phenylalanine 4 (Aβ4‐x) in Alzheimer's disease and cerebral amyloid angiopathy preclinical studies (in vitro and in vivo models).
Maria Luisa Valle, Donatello Arienzo
wiley   +1 more source

Migrant Top Management Team and Corporate Innovation: Evidence From China

Accounting &Finance, Volume 66, Issue 1, Page 497-531, March 2026.
ABSTRACT This study explores the association between top management teams (TMT) comprised of migrant managers (migrant TMT) and corporate innovation. Using hand‐collected data for a sample of Chinese A‐share listed firms spanning the period 2008–2020, we find a positive and significant association between a migrant TMT and corporate innovation.
Ying Liu, Ahsan Habib, Hedy Jiaying Huang   +2 more
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo

Lipids in Health and Disease, 2018
Background The fibrillation of islet amyloid polypeptide (IAPP) triggered the amyloid deposition, then enhanced the loss of the pancreatic islet mass. However, it is not clear what factor is the determinant in development of the fibril formation. The aim
Xiao-Dan Mo, Li-Ping Gao, Qing-Jun Wang, Jie Yin, Yu-Hong Jing   +4 more
doaj   +1 more source

A Survey on Handover Management in Mobility Architectures

, 2015
This work presents a comprehensive and structured taxonomy of available techniques for managing the handover process in mobility architectures. Representative works from the existing literature have been divided into appropriate categories, based on ...
Ferretti, Stefano, Ghini, Vittorio, Panzieri, Fabio   +2 more
core   +1 more source

Electrochemical Anodization as a Reliable and Sustainable Processes for Gate Dielectrics in Organic Thin‐Films Transistors

ChemElectroChem, Volume 13, Issue 4, 17 February 2026.
Electrochemical anodization enables precise, self‐aligned formation of robust oxide dielectrics under mild conditions. This concept explores its role in advancing low‐voltage, high‐frequency organic transistors, highlighting how this scalable and sustainable technique may reshape flexible electronics, from planar organic thin‐film transistors to ...
Juan Wang, Amric Bonil, Hans Kleemann
wiley   +1 more source