Evaluation of the transverse aortic constriction model in ICR and C57BL/6J mice
Frontiers in Physiology, 2022 Transverse aortic constriction (TAC) is a frequently used model to investigate pressure overload-induced progressive heart failure (HF); however, there is considerable phenotypic variation among different mouse strains and even sub-strains.
Mengying Huang +18 more
doaj +3 more sources
Inflammation of the cardiac coronary artery in ICR mice. [PDF]
J Toxicol Pathol, 2022 Inflammation of the cardiac coronary artery in ICR mice is occasionally observed in toxicity studies; however, this has not been well explored histologically. Herein, we investigated the detailed histology of the associated lesions in 6-8-week-old ICR mice. Coronary artery inflammation in the right ventricular wall was observed in 10 of 142 mice (7.0%).
Yasuno K +5 more
europepmc +3 more sources
Susceptibility and transcriptional characteristics of inbred C57BL/6J and outbred ICR mice in CDAHFD-induced MASH models [PDF]
Laboratory Animal ResearchBackground Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive fibrotic liver disease, the underlying mechanisms of which have not been fully elucidated.
Jing Zhou +9 more
doaj +2 more sources
Animal Model Screening for Hyperlipidemic ICR Mice. [PDF]
Int J Mol SciThis study aimed to establish a hyperlipidemia model in ICR mice using a homemade high-fat diet. It further investigated hyperlipidemia-related indicators in control and model mice at various feeding durations to determine the optimal time frame for successful model establishment.
Chen X +6 more
europepmc +3 more sources
Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice. [PDF]
Int J Mol Sci, 2023 Currently, polypropylene (PP) is used in various products, thus leading to high daily exposure in humans. Thus, it is necessary to evaluate the toxicological effects, biodistribution, and accumulation of PP microplastics in the human body. In this study, administration of two particle sizes of PP microplastics (approximately 5 and 10–50 µm) did not ...
Lee S +12 more
europepmc +3 more sources
Characterization of odor markers associated with aging in old ICR mice [PDF]
Scientific ReportsTo identify and characterize the novel odor markers associated with aging in mice, alterations in the concentration of odorants in the urine, expression of metabolic enzymes, the histopathological structure of the sweat glands, and the expression of ...
Ji Eun Kim +8 more
doaj +2 more sources
In Vivo Toxicity and Pharmacokinetics of Polytetrafluoroethylene Microplastics in ICR Mice. [PDF]
Polymers (Basel), 2022 The increased use of plastics has led to severe environmental pollution, particularly by microplastics—plastic particles 5 mm or less in diameter. These particles are formed by environmental factors such as weathering and ultraviolet irradiation, thereby making environmental pollution worse.
Lee S +12 more
europepmc +3 more sources
Sex differences in placental structure and gene expression in ICR mice during embryonic development [PDF]
Scientific ReportsThe placenta is a vital organ for fetal development, providing structural support and mediating both nutrient exchange and maternal–fetal immune interactions.
Xinyi Man +3 more
doaj +2 more sources
Neurosecretory Protein GL Promotes Normotopic Fat Accumulation in Male ICR Mice [PDF]
International Journal of Molecular Sciences, 2022 Yuki Narimatsu +2 more
exaly +2 more sources
Pulmonary Toxicity of Polystyrene, Polypropylene, and Polyvinyl Chloride Microplastics in Mice
Molecules, 2022 Globally, plastics are used in various products. Concerns regarding the human body’s exposure to plastics and environmental pollution have increased with increased plastic use.
Isaac Kwabena Danso +2 more
doaj +1 more source