Results 21 to 30 of about 40,233 (217)

Characteristics of Scratching Behavior Induced by Some Chemical Mediators in Hairless Mice

open access: yesJournal of Pharmacological Sciences, 2006
.: To find the characteristics of scratching behavior in hairless mice (HR-1), compound 48/80 and some putative chemical mediators of allergic reaction were injected intradermally into the backs of mice, and the number of scratching behaviors was ...
Miho Takubo   +5 more
doaj   +1 more source

Comparison of the response using ICR mice derived from three different sources to multiple low-dose streptozotocin-induced diabetes mellitus

open access: yesLaboratory Animal Research, 2017
This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources.
Do Yeon Lee   +5 more
doaj   +1 more source

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. [PDF]

open access: yesPLoS Genetics, 2017
The cytoplasmic peptide:N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme that is highly conserved among eukaryotes. It was recently reported that subjects harboring mutations in the NGLY1 gene exhibited severe systemic symptoms (NGLY1 ...
Haruhiko Fujihira   +12 more
doaj   +1 more source

Intravenous transplantation of mouse embryonic stem cells attenuates demyelination in an ICR outbred mouse model of demyelinating diseases

open access: yesNeural Regeneration Research, 2016
Induction of demyelination in the central nervous system (CNS) of experimental mice using cuprizone is widely used as an animal model for studying the pathogenesis and treatment of demyelination.
Kidsadagon Pringproa   +4 more
doaj   +1 more source

Generation of embryonic stem cells derived from the inner cell mass of blastocysts of outbred ICR mice

open access: yesAnimal Cells and Systems, 2020
Embryonic stem cells (ESCs) derived from outbred mice which share several genetic characteristics similar to humans have been requested for developing stem cell-based bioengineering techniques directly applicable to humans. Here, we report the generation
Na Rae Han   +8 more
doaj   +1 more source

Acute and Subacute Toxicity of Fluorescent Gold Nanoclusters Conjugated with α-Lipoic Acid

open access: yesNanomaterials, 2022
Fluorescent gold nanoclusters conjugated with α-lipoic acid (FANC) is a promising biocompatible fluorescent nanomaterial with a high potential for drug development.
Yun-Fang Chen   +2 more
doaj   +1 more source

Osteosclerosis in aged ICR mice.

open access: yesThe Japanese Journal of Veterinary Science, 1985
Osteosclerosis occurred in a high incidence in the sternum and tibia of 160 ICR mice examined histologically, at more than 300 days of age in the females and at more than 450 days of age in the males. It was initiated with a proliferation of osteogenous tissues at the metaphysis, resulting in replacement of the marrow cavity by a network of mature ...
YAMASAKI, Kanji, ITAKURA, Chitoshi
openaire   +3 more sources

Study on the Ophthalmic Diseases in ICR Mice and BALB/c Mice

open access: yesExperimental Animals, 2006
In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests.
PARK, Shin Ae   +10 more
openaire   +3 more sources

Establishment of a mouse model of 70% lethal dose by total-body irradiation

open access: yesLaboratory Animal Research, 2016
Whereas increasing concerns about radiation exposure to nuclear disasters or side effects of anticancer radiotherapy, relatively little research for radiation damages or remedy has been done. The purpose of this study was to establish level of LD70/30 (a
Seung-Hyun Ryu   +11 more
doaj   +1 more source

Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms

open access: yesCommunications Biology, 2021
Hitomi Matsuzaki et al. test the effect of reversing the H19/Igf2 imprinting control region (ICR) in mice. Their results suggest that the polarity of the ICR is involved in controlling imprinted H19 expression in both parental alleles, dependent or ...
Hitomi Matsuzaki   +3 more
doaj   +1 more source

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