Results 131 to 140 of about 618,162 (164)

Rational design of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors featuring 1,2,3-triazole derivatives with enhanced anti-inflammatory and analgesic efficacy. [PDF]

Front Pharmacol
Liu Q, Hou X, Wang Y, Tian M, He B, Guo J, Yang J.   +6 more
europepmc   +1 more source

Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness. [PDF]

J Immunother Cancer
Shen SC, Dey S, DuHadaway JB, Sutanto-Ward E, Hampton MT, Kozlov SV, Prendergast GC, Muller AJ.   +7 more
europepmc   +1 more source

Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. [PDF]

Medchemcomm, 2019
Wang XX, Sun SY, Dong QQ, Wu XX, Tang W, Xing YQ.   +5 more
europepmc   +1 more source

Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'. [PDF]

Trends Cancer, 2018
Prendergast GC, Mondal A, Dey S, Laury-Kleintop LD, Muller AJ.   +4 more
europepmc   +1 more source

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor. [PDF]

Toxicol Appl Pharmacol, 2017
Moyer BJ, Rojas IY, Murray IA, Lee S, Hazlett HF, Perdew GH, Tomlinson CR.   +6 more
europepmc   +1 more source

Compensatory pathways in tryptophan metabolism and immune regulation following IDO inhibition. [PDF]

Mol Biol Rep
Gontijo I, Camurça M, Kfoury JR.
europepmc   +1 more source

Editorial Comment on "Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression": Rethinking the Tryptophan-Kynurenine Pathway in Urological Cancer Immunotherapy. [PDF]

Int J Urol
Almulla AF, Zhang Y, Maes M.
europepmc   +1 more source

Phytochemical Modulation of the Kynurenine Pathway (KYNP) and Its Emerging Mechanistic Insights into Cancer Progression: A Systematic Review. [PDF]

Int J Mol Sci
Tsantila EM, Christodoulou MC, Esslinger N, Neophytou CM.   +3 more
europepmc   +1 more source

Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling. [PDF]

J Med Chem
Rezzi SJ, Butticè A, Villani S, Lesca G, Rossini S, Panfili E, Mazzoletti D, Bari E, Violante D, Serafini M, Massarotti A, Orabona C, Pallotta MT, Aprile S, Fallarini S, Del Grosso E, Di Martino RMC, Miggiano R, Pirali T.   +18 more
europepmc   +1 more source

Drug Discovery of Allosteric Molecular Glue Degraders (aMGDs): Expanding the Landscape of Targeted Protein Degradation. [PDF]

J Med Chem
Xue Y, Ali S, Chen H, Zhou J.
europepmc   +1 more source