Results 21 to 30 of about 618,162 (164)
Discovery of IDO1 Inhibitors: From Bench to Bedside. [PDF]
Cancer Res, 2017 Small-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide a bench-to-bedside review on preclinical validation of IDO1 as a cancer ...
Prendergast GC +3 more
europepmc +2 more sources
Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls. [PDF]
Int J Mol Sci, 2022 Over the last two decades, indoleamine 2,3-dioxygenase 1 (IDO1) has attracted wide interest as a key player in immune regulation, fostering the design and development of small molecule inhibitors to restore immune response in tumor immunity.
Mammoli A +12 more
europepmc +2 more sources
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2020 Wensheng Yu +2 more
exaly +2 more sources
Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold. [PDF]
Pharmaceuticals (Basel), 2021 Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one ...
Dolšak A +6 more
europepmc +2 more sources
Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources
Frontiers in Pharmacology, 2022 L-tryptophan metabolism is involved in the regulation of many important physiological processes, such as, immune response, inflammation, and neuronal function.
Ying Tan +4 more
doaj +1 more source
, 2021 Indoleamine 2,3-dioxygenase-1 (IDO1) plays an important role in tumor immune escape. However, unsatisfactory clinical efficacies of selective IDO1 inhibitors have impeded their further development, suggesting that they do not exert sufficient antitumor ...
Zhaoxing Chu (7536365) +13 more
core +3 more sources
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy [PDF]
ACS Medicinal Chemistry Letters, 2019 Wensheng Yu +2 more
exaly +2 more sources
Food Chemistry: X, 2023 In this study, a ligand fishing method was developed to screen potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors from coffee extracts by immobilization of IDO1 enzyme on amino-modified magnetic nanoparticles combined with UHPLC-Q-TOF-MS/MS ...
Zhuoting Liu +5 more
doaj +1 more source
Research progress of indoleamine 2,3-dioxygenase 1 in gastric cancer
生物医学转化, 2023 Gastric cancer is the fifth most common malignant tumor and fourth leading cause of cancerrelated deaths worldwide. Gastric cancer has obvious heterogeneity and complex tumor microenvironment. Although immune checkpoint inhibitors have shown certain anti-
Pei Xiaxia +6 more
doaj +1 more source
Biomedicines, 2023 Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme enzyme involved in catalyzing the conversion of tryptophan (Trp) into kynurenine (Kyn) at the first rate-limiting step in the kynurenine pathway of L-tryptophan metabolism.
Pengbo Yang, Junhua Zhang
doaj +1 more source