Results 31 to 40 of about 618,162 (164)

Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO

Frontiers in Immunology, 2021
Blockade of the immunosuppressive tryptophan catabolism mediated by indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) holds enormous promise for sensitising cancer patients to immune checkpoint blockade.
Minah Kim, Petr Tomek
doaj   +1 more source

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold [PDF]

ACS Medicinal Chemistry Letters, 2018
Kurt Stover, Donald Weaver
exaly   +2 more sources

Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

, 2021
The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays an essential role in immunity, neuronal function, and aging through catalysis of the rate-limiting step in the kynurenine pathway of tryptophan metabolism.
Michielin, O., Reynaud, A., Reynaud, Aline, Majjigapu, S.R., Rohrig, Ute F., Coukos, George, Vogel, P., Ascencao, Kelly, Reichenbach, Patrick, Pojer, Florence, Reichenbach, P., Irving, Melita, Michielin, Olivier, Zoete, Vincent, Majjigapu, Somi Reddy, Ascencao, K., Zoete, V., Irving, M., Dilek, Nahzli, Röhrig, U.F., Pojer, F., Dilek, N., Coukos, G., Vogel, Pierre   +23 more
core   +1 more source

Development of a DNA aptamer targeting IDO1 with anti-tumor effects

iScience, 2023
Summary: Immune checkpoint blockade has become an effective approach to reverse the immune tolerance of tumor cells. Indoleamine 2,3-dioxygenase 1 (IDO1) is frequently upregulated in many types of cancers and contributes to the establishment of an ...
Zhenyu Zhu, Zeliang Yang, Chuanda Zhu, Zixi Hu, Zhongyu Jiang, Jingjing Gong, Yuyao Yuan, Xi Chen, Yan Jin, Yuxin Yin   +9 more
doaj   +1 more source

GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer

Frontiers in Immunology, 2021
IDO1-mediated immune escape can lead to the malignant progression of tumors. However, the precise mechanism of IDO1 remains unclear. This study showed that IDO1 can bind to GBP1 and increase the extracellular secretion of IDO1 with the assistance of GBP1,
Yinnan Meng, Wei Wang, Meng Chen, Kuifei Chen, Xinhang Xia, Suna Zhou, Haihua Yang, Haihua Yang   +7 more
doaj   +1 more source

Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma

ESMO Open, 2020
Background We sought to determine the prognostic role of indoleamine 2,3-dioxygenase 1 (IDO1) by evaluating IDO1 expression in circulating tumour cells (CTCs) at baseline and after completion of chemoradiotherapy in patients with locally advanced (LA ...
Amanda Psyrri, Evangelos Giotakis, Panagiota Economopoulou, Athina Kladi-Skandali, Areti Strati, George Koytsodontis, Efthymios Kirodimos, Pavlos Maragoudakis, Eleni Gagari, Eirini Maratou, George Dimitriadis, Ioannis Kotsantis, Elena Vagia, Maria Anastasiou, Maria Gkotzamanidou, George Kavourakis, Evi Lianidou   +16 more
doaj   +1 more source

Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

European Journal of Medicinal Chemistry Reports, 2023
Herein, we report the development of synthetically simpler analogs of 4,7-dichloroquinoline (DCQ) as apo-indoleamine 2,3-dioxygenase 1(IDO1) protein targeting ligand to inhibit the activity of IDO1 enzyme.
Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna   +8 more
doaj   +1 more source

What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past

Journal of Experimental & Clinical Cancer Research, 2021
Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function.
Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang   +8 more
doaj   +1 more source

The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1

Frontiers in Immunology, 2023
Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan metabolizing enzyme chronically activated in many cancer patients and its expression and activity correlate with a poor prognosis.
Eleonora Panfili, Giada Mondanelli, Ciriana Orabona, Marco Gargaro, Claudia Volpi, Maria Laura Belladonna, Sofia Rossini, Chiara Suvieri, Maria Teresa Pallotta   +8 more
doaj   +1 more source

Boron as a platform for small molecule IDO1 inhibitors [PDF]

, 2021
The metabolic breakdown of the essential amino acid L-tryptophan is controlled by three dioxygenase enzymes: indoleamine-2,3-dioxygenase 1 (IDO1), indoleamine-2,3-dioxygenase 2 (IDO2), and tryptophan-2,3-dioxygenase(TDO).
Dasgupta, Samrat
core