Results 41 to 50 of about 618,162 (164)

Targeting the IDO1 pathway in cancer: from bench to bedside

Journal of Hematology & Oncology, 2018
Indoleamine 2, 3-dioxygenases (IDO1 and IDO2) and tryptophan 2, 3-dioxygenase (TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into kynurenine.
Ming Liu, Xu Wang, Lei Wang, Xiaodong Ma, Zhaojian Gong, Shanshan Zhang, Yong Li   +6 more
doaj   +1 more source

Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor Effects

Molecules, 2023
Indoleamine-2,3-dioxygenase 1 (IDO1) and signal transducer and activator of transcription 3 (STAT3) have emerged as significant targets in the tumor microenvironment for cancer therapy. In this study, we synthesized three novel 2-amino-1,4-naphthoquinone
Ri-Zhen Huang, Qiao-Ling Liang, Xiao-Teng Jing, Ke Wang, Hui-Yong Zhang, Heng-Shan Wang, Xian-Li Ma, Jian-Hua Wei, Ye Zhang   +8 more
doaj   +1 more source

IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10

Pharmacological Research, 2022
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in tryptophan catabolism along the kynurenine (Kyn) pathway and exerts immunosuppressive properties mainly via activation of transcription factor aryl hydrocarbon receptor (AhR ...
Xin Fang, Leilei Guo, Zikang Xing, Lei Shi, Heng Liang, Aiying Li, Chunxiang Kuang, Bangbao Tao, Qing Yang   +8 more
doaj   +1 more source

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Signal Transduction and Targeted Therapy, 2022
Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8+ T cells, is regulated by several intrinsic signaling pathways.
Fan Liang, Gui-Zhen Wang, Yan Wang, Ya-Ning Yang, Zhe-Sheng Wen, Dong-Ni Chen, Wen-Feng Fang, Bin Zhang, Lu Yang, Chen Zhang, Si-Chong Han, Fu-Ying Yang, Di Wang, Li-Jun Liang, Zheng Wang, Yong Zhao, Chang-Li Wang, Li Zhang, Guang-Biao Zhou   +18 more
doaj   +1 more source

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

, 2016
Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as a promising target for the treatment of several diseases, including neurological disorders and cancer.
Tomoyuki Tanaka (1738816), Tetsuya Kohno (1738807), Shigehiro Asano (1331397), Seiji Kamioka (1738804), Yosuke Ota (433924), Takayuki Ishii (1738813), Keiko Kamimoto (1738810), Yoshiaki Isobe (1721080), Shingo Tojo (1738819)   +8 more
core   +1 more source

Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening

Frontiers in Pharmacology, 2018
Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular monomeric heme-containing enzyme that catalyzes the first and the rate limiting step in catabolism of tryptophan via the kynurenine (KYN) pathway, which plays a significant role in the ...
Guoqing Zhang, Guoqing Zhang, Jing Xing, Jing Xing, Yulan Wang, Yulan Wang, Lihao Wang, Yan Ye, Yan Ye, Dong Lu, Dong Lu, Jihui Zhao, Jihui Zhao, Xiaomin Luo, Mingyue Zheng, Shiying Yan   +15 more
doaj   +1 more source

Discovery of novel 4-hydroxyquinolines as indoleamine 2, 3-dioxygenase 1 inhibitors by virtual screening

Di-san junyi daxue xuebao, 2019
Objective To discover novel indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors with new scaffold structures by screening ZINC and Chembridge databases using pharmacophore modeling and molecular docking.
ZHANG Yuping, SHAN Changyu, GUO Haiqiong
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Indoleamine 2,3-dioxygenase 1 (IDO1), a tryptophan catabolising enzyme, is known as a tumour cell survival factor that causes immune escape in several types of cancer.
Mincheol Kwon, Sung-Kyun Ko, Mina Jang, Gun-Hee Kim, In-Ja Ryoo, Sangkeun Son, Hyung Won Ryu, Sei-Ryang Oh, Won-Kyu Lee, Bo Yeon Kim, Jae-Hyuk Jang, Jong Seog Ahn   +11 more
doaj   +1 more source

Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0

Frontiers in Immunology, 2021
Indoleamine 2,3-dioxygenase (IDO1) is a key regulator of immune suppression by catalyzing the oxidation of L-tryptophan. IDO1 expression has been related to poor prognosis in several cancers and to resistance to checkpoint immunotherapies.
Yvonne Grobben, Jos de Man, Antoon M. van Doornmalen, Michelle Muller, Nicole Willemsen-Seegers, Diep Vu-Pham, Winfried R. Mulder, Martine B. W. Prinsen, Joeri de Wit, Jan Gerard Sterrenburg, Freek van Cauter, Judith E. den Ouden, Anne M. van Altena, Leon F. Massuger, Joost C. M. Uitdehaag, Rogier C. Buijsman, Guido J. R. Zaman   +16 more
doaj   +1 more source