Results 41 to 50 of about 101,358 (257)

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Membrane-associated insulin-like growth factor (IGF) binding structures in placental cells [PDF]

Journal of the Serbian Chemical Society, 2003
The biological activities of IGF-I and –II are mediated mainly by the type 1 IGF receptor (IGF 1R) and controlled by their interaction with soluble proteins, the IGF binding proteins (IGFBPs). Although there is a growing body of evidence that some IGFBPs
Masnikosa Romana M., Nikolić-Judith Anna, Nedić Olgica R.   +2 more
doaj   +3 more sources

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.

PLoS ONE, 2019
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett, Eileen Hsu, Justin M Thomas, Joseph M Pilewski, Carol Feghali-Bostwick   +4 more
doaj   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway

Frontiers in Cellular Neuroscience
Insulin-like growth factor-1 (IGF-1) is a single chain polypeptide hormone that plays an essential role in intrauterine and postnatal growth. Recent studies suggest that IGF-1 and its receptor IGF-1R are involved in the pathogenesis of neurological ...
Yanli Tang, Rui Zhong, Jiayi Liang, Shuang Liu, Wanxia Liu, Tao Liu, Baohong Yuan, Baohong Yuan, Mengya Jiao, Mengya Jiao, Mengya Jiao, Hui Yin, Hui Yin   +12 more
doaj   +1 more source

Endothelial Insulin and IGF-1 Receptors: When Yes Means NO [PDF]

Diabetes, 2012
Cardiovascular (CV) disease is the leading cause of morbidity and mortality and a major driver of health care costs in patients with type 2 diabetes. Observational studies suggest that insulin resistance and hyperglycemia independently predict atherosclerosis (1,2).
Muniyappa, Ranganath, Sowers, James R.
openaire   +2 more sources

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10. [PDF]

PLoS ONE, 2012
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues. We report a series of experiments forming a comprehensive characterisation of the long acting insulin analogues, glargine and detemir, in comparison ...
Bo F Hansen, Tine Glendorf, Anne C Hegelund, Anders Lundby, Anne Lützen, Rita Slaaby, Carsten Enggaard Stidsen   +6 more
doaj   +1 more source

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

Diabetes, 2012
We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair.
Imrie, H, Viswambharan, H, Sukumar, P, Abbas, A, Cubbon, RM, Yuldasheva, N, Gage, M, Smith, J, Galloway, S, Skromna, A, Rashid, ST, Futers, TS, Xuan, S, Gatenby, VK, Grant, PJ, Channon, KM, Beech, DJ, Wheatcroft, SB, Kearney, MT   +18 more
openaire   +4 more sources