Results 41 to 50 of about 152,806 (342)

Changes in Insulin-Like Growth Factor-I and -II Associated with Fat but not Lean Mass in Early Old Age [PDF]

, 2015
Objective: To test the hypothesis that insulin-like growth factors-I and II (IGF-I and II) decline during late midlife and that greater declines are related to higher fat mass and lower lean mass.
Adams, Andersen, Ben-Shlomo, Benn, Berryman, Bidlingmaier, Birnie, Burgers, Chaston, Cooper, Crowe, Crowe, Firth, Flegal, Harris, Holly, Holt, Huang, Jakobsdottir, Junnila, Klinger, Kuh, Kuk, Livingstone, Lukanova, Martin, Nindl, Nindl, Nindl, O'Connor, Parekh, Rejeski, Rodriguez, Sandhu, Schrager, Seck, Soubry, Vestergaard, Wolfe, Ye   +39 more
core   +2 more sources

Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway

Biomedicines
Aim: The liver is the major source of circulating insulin-like growth factor (IGF)-I. Serum IGF-I levels are decreased in cirrhotic patients depending on severity.
Takako Nishikawa, Natsuko Ohtomo, Yukiko Inoue, Mami Takahashi, Hitoshi Ikeda, Kazuhiko Koike, Nobutake Yamamichi, Mitsuhiro Fujishiro, Tomoaki Tomiya   +8 more
doaj   +1 more source

IGF-I and the aging mammalian brain

Experimental Gerontology, 2011
Insulin-like growth factors (IGFs) are important modulators of organismal life-span all along phylogeny. These growth factors are widely viewed as detrimental for long life by reducing tissue resistance to oxidative stress. However, IGF-I has been consistently shown to be a potent neuroprotective factor in mammals, and as such, a deterrent of brain ...
Piriz, Joaquin, Muller, A., Trejo, J. L., Torres Aleman, I.   +3 more
openaire   +5 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth [PDF]

, 2000
OBJECTIVE: Serum IGF-I levels are monitored during GH replacement treatment in adults with GH defi- ciency (GHD) to guide GH dose adjustment and to minimize occurrence of GH-related side-effects.
Clayton, P.E., Gill, M.S., Kibirige, M.S., Patel, L., Price, D.A., Tillman, V., Wales, J.K., Whatmore, A.J.   +7 more
core  

Relation of IGF-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and NT-proBNP

Endocrine Connections, 2019
Objective: Several studies revealed relations between low or high insulin -like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms be hind these associations are still unknown.
Maximilian Eichner, Henri Wallaschofski, Ulf Schminke, Henry Völzke, Marcus Dörr, Stephan B Felix, Matthias Nauck, Nele Friedrich   +7 more
doaj   +1 more source

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

Molecular Therapy: Nucleic Acids, 2023
Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases ...
Justin S. Antony, Pascale Birrer, Claudia Bohnert, Sina Zimmerli, Petra Hillmann, Hervé Schaffhauser, Christine Hoeflich, Andreas Hoeflich, Ramzi Khairallah, Andreas T. Satoh, Isabelle Kappeler, Isabel Ferreira, Klaas P. Zuideveld, Friedrich Metzger   +13 more
doaj  

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Alternative Leader-Exon Usage in Mouse IGF-I mRNA Variants: Class 1 and Class 2 IGF-I mRNAs [PDF]

, 2007
The mouse IGF-I gene contains six exons, and exon 1 and exon 2 gene are considered to be leader exons. The regulatory mechanism of alternative usage of the leader exons is unclear in mice.
Hirata, Kensaku, Murakami, Yousuke, Ohtsuki, Takashi, Otsuki, Mariko, Takahashi, Sumio, Takeuchi, Sakae   +5 more
core   +1 more source