Autocrine IGF-II-Associated Cancers: From a Rare Paraneoplastic Event to a Hallmark in Malignancy [PDF]
Biomedicines, 2023 The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood ...
Pierluigi Scalia +6 more
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Determinants of IGF-II influencing stability, receptor binding and activation [PDF]
Scientific Reports, 2022 Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth.
Andrew Blyth +4 more
doaj +2 more sources
Understanding IGF-II Action through Insights into Receptor Binding and Activation [PDF]
Cells, 2020 The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and ...
Andrew J. Blyth +2 more
doaj +2 more sources
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids [PDF]
Redox Biology, 2017 Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in a wide range of neurodegenerative diseases and ageing.
E. Martín-Montañez +8 more
doaj +3 more sources
Re-expression of IGF-II is important for beta cell regeneration in adult mice. [PDF]
PLoS ONE, 2012 The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the adult is ...
Luxian Zhou +8 more
doaj +9 more sources
Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. [PDF]
PLoS ONE, 2019 Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett +4 more
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Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis [PDF]
Frontiers in Endocrinology, 2021 Multiple sclerosis (MS) is a chronic autoimmune disease of the brain and spinal cord causing a wide range of symptoms such as impaired walking capability, spasticity, fatigue, and pain. The insulin-like growth factor (IGF) system has regulatory functions
Andreas Hoeflich +6 more
doaj +2 more sources
The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]
Am J Physiol Endocrinol Metab, 2016 Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Charnock JC +5 more
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Redox Biology, 2021 Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez +13 more
doaj +1 more source
Stem Cell Research & Therapy, 2020 Background Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome.
Yi Sui +8 more
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