Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]
, 1992 Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg +5 more
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Insulin-Like Growth Factor (IGF)-I and -11 and IGFBinding Proteins-l, -2, and -3 in Children and Adolescents with Diabetes Mellitus: Correlation with Metabolic Control and Height Attainment. [PDF]
, 1995 The putative effects of diabetes and metabolic control on circulating levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) remain controversial.
Blum, Werner F. +6 more
core +1 more source
Keeping IGF-II under control: Lessons from the IGF-II–IGF2R crystal structure
Trends in Biochemical Sciences, 2009 Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs ...
Brown, J., Jones, E., Forbes, B.
openaire +4 more sources
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos [PDF]
, 1992 We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages, mRNA and protein for IGF-II were expressed in ...
Behrendtsen, Ole +5 more
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IGF-II Promotes Stemness of Neural Restricted Precursors [PDF]
Stem Cells, 2012 Abstract Insulin-like growth factor (IGF)-I and IGF-II regulate brain development and growth through the IGF type 1 receptor (IGF-1R). Less appreciated is that IGF-II, but not IGF-I, activates a splice variant of the insulin receptor (IR) known as IR-A.
Amber N, Ziegler +7 more
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International Journal of Endocrinology, 2015 African American women suffer higher incidence and mortality of triple negative breast cancer (TNBC) than Caucasian women. TNBC is very aggressive, causing the worst clinical outcome.
Vinodh Kumar Radhakrishnan +5 more
doaj +1 more source
Frontiers in Endocrinology, 2013 Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor.
Soetkin eVersteyhe +7 more
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Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer [PDF]
, 2015 The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment.
Daniela A. Ferraro +6 more
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Neurobiology of Disease, 2015 Studies have showed that prenatal cocaine exposure (PCOC) can impair cognitive function and social behavior of the offspring; however, the mechanism underlying such effect is poorly understood.
Qian Zhao +17 more
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Eating in an extreme environment: diet of the European hare (Lepus europaeus) on Vesuvius
The European Zoological Journal, 2022 The European hare (Lepus europaeus) is cosmopolitan species, living in a variety of habitats and showing a diversified diet, that has been described mainly from agricultural meadows and crops, with little information available for extreme environments ...
M. Buglione +3 more
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