Reproductive Biology and Endocrinology, 2003 Testis tumors occur frequently in dogs. The main types of tumors are Sertoli cell tumors, seminomas, and Leydig cell tumors. Mixed tumors and bilateral occurrence of tumors may be encountered frequently. To elucidate the possible relationship between the
Oosterlaken-Dijksterhuis Marja A +5 more
doaj +1 more source
Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]
, 2014 The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 (mTOR complex 1) activation with the ...
Amy Patton +12 more
core +5 more sources
Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities
Frontiers in EndocrinologyProstate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam +10 more
doaj +1 more source
High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin [PDF]
, 2001 Mannose-6-phosphate (man-6-P)/insulin-like growth factor-II (man-6-P/IgF-II) receptors are involved in the activation of recombinant human prorenin by cardiomyocytes.
Bruin, R.J.A. (René) de +7 more
core
Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]
, 2016 Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta +59 more
core +2 more sources
A case of extragastrointestinal stromal tumor complicated by severe hypoglycemia: a unique presentation of a rare tumor [PDF]
, 2016 BACKGROUND: Non-Islet Cell Tumor Hypoglycemia (NICTH) is a rare paraneoplastic cause of hypoglycemia arising from excess tumor production of insulin-like growth factor.
Evans-Molina, Carmella +2 more
core +1 more source
Els glucocortidoides : inhibidors del creixement [PDF]
, 2009 L'article següent analitza el paper dels glucocorticoides en la inhibició del creixement fetal en humans. Fins ara, s'ha sabut que l'acció localitzada dels GCs sobre el cartíleg del creixement afecta directament a agents com els factors de creixement ...
Carrascosa Lezcano, Antonio
core +1 more source
Changes in Insulin-Like Growth Factor-I and -II Associated with Fat but not Lean Mass in Early Old Age [PDF]
, 2015 Objective: To test the hypothesis that insulin-like growth factors-I and II (IGF-I and II) decline during late midlife and that greater declines are related to higher fat mass and lower lean mass.
Adams +39 more
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Российский офтальмологический журнал, 2018 Studying immunological aspects of pathogenesis of retinopathy of prematurity (ROP) helps develop new approaches to prevention, rational diagnosis and increase of the effectiveness of treatment of the disease.
L. A. Katargina +3 more
doaj +1 more source
Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]
, 2005 We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Andress +40 more
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