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IL-1 Family Members in Bone Sarcomas. [PDF]

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Landuzzi L   +5 more
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IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.

The Journal of Immunology, 1990
Abstract IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial cells. IL-1-induced IL-1 may be part of a self-amplification or an autocrine growth factor in a variety of responses, and thus the endogenous regulation of IL-1 production likely contributes to the outcome of immunologic or ...
Schindler, R, Ghezzi, P, Dinarello, C A
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IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.

The Journal of Immunology, 1988
Abstract IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory diseases. We have recently shown that IL-1 induces its own gene expression and, in the present studies, we have examined the effect of IFN-gamma on IL-1-induced IL-1 production. Whereas IFN-gamma increases the total amount of IL-1 (
Ghezzi, P, Dinarello, C A
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Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity

Cellular Immunology, 1992
Previous work from our laboratory has shown that rabbit articular chondrocytes, like macrophages, produce reactive oxygen intermediates, express Ia antigen, and can mediate immunologic functions such as antigen presentation and induction of mixed and autologous lymphocyte reactions.
K, Tiku   +3 more
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