Results 251 to 260 of about 28,037,829 (342)

BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells. [PDF]

J Biol Chem
Nord JA, Makowski SJ, Sidlowski PFW, Bursch KL, Corbett JA, Smith BC.   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells. [PDF]

Int J Mol Sci
Mazzone A, Della Rocca Y, Flamminii F, Guarnieri S, Bello DG, Nanci A, Trubiani O, Diomede F, Pizzicannella J.   +8 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

SO27. First Rib-Sparing Vs. Rib Resection in Thoracic Outlet Syndrome: Functional Outcomes in 105 Patients

Plastic and Reconstructive Surgery, Global Open
Iulianna Taritsa, BA, Kazimir Bagdady, BS, Cristin Coquillard, MD, Hannah Soltani, BS, Rolando Casas Fuentes, BS, Timothy Burke, BA, Rushmin Khazanchi, BA, Puja Jagasia, BA, Lindsay Janes, MD, Ashley Vavra, MD, Jason H. Ko, MD, MBA, FACS   +10 more
doaj   +1 more source

IL-1 modulation preserves biomolecular, structural and functional integrity of the somatosensory cortex after fetal inflammation

Galinsky R, Kelly S, Cho S, Zahra V, Menyen M, Hunt R, Nold-Petry C, Gunn A, Polglase G, Hooper S, Nold M.   +10 more
europepmc   +1 more source

Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma. [PDF]

Mol Ther Oncol
Yun K, Sakemura RL, Can I, Gutierrez Ruiz O, Ogbodo EJ, Zhang S, Saleh A, Huynh TN, Manriquez Roman C, Sirpilla OL, Stewart CM, Girsch JH, Feigin JM, Mai L, Xia H, Kimball B, Kankeu Fonkoua LA, Hefazi M, Ruff MW, Rohakhtar FR, Simon V, Siegler EL, Mattie M, Nguyen-Mau SM, Filosto S, Kenderian SS.   +25 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

22. Enhancing The Accuracy Of Planned Surgery With Computer Controlled Osteotomies

Plastic and Reconstructive Surgery, Global Open
Naji Bou Zeid, MD, Devansh Saini, PhD, George R. Nahass, BS, Weiqiao Zeng, PhD, He Tong-Chuan, PhD, Russel R. Reid, MD, PhD, Pravin K. Patel, MD, Lee Alkureishi, MD   +7 more
doaj   +1 more source

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer. [PDF]

Sci Rep
Toney NJ, Opdenaker LM, Frerichs L, Modarai SR, Ma A, Archinal H, Ajayi GO, Sims-Mourtada J.   +7 more
europepmc   +1 more source