Results 81 to 90 of about 82,847,056 (224)

Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27

Clinical and Developmental Immunology, 2010
The interleukin (IL)-12 family, which is composed of heterodimeric cytokines including IL-12, IL-23, and IL-27, is produced by antigen-presenting cells such as macrophages and dendritic cells and plays critical roles in the regulation of helper T (Th ...
Mingli Xu, Izuru Mizoguchi, Noriko Morishima, Yukino Chiba, Junichiro Mizuguchi, Takayuki Yoshimoto   +5 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Human IFN-gamma immunity to mycobacteria is governed by both IL-12 and IL-23

, 2018
Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12R beta 1 deficiency have been diagnosed over the last 20 years. They typically suffer from invasive mycobacteriosis and, occasionally, from mucocutaneous candidiasis. Susceptibility
Ramirez-Alejo N, Patin E, Sette A, Tabarsi P, Deenick EK, Lazarov T, Puel A, Schmidt M, Geissmann F, Di Santo JP, Rao G, Arlehamn CL, Bloursaz MR, Mandaviani SA, Nieto-Patlan A, Kong XF, Abel L, Casanova JL, Mele F, Heer A, Ma CS, Deswarte C, Bustamante J, Tanir G, van de Vosse E, Rapaport F, Aytekin C, Boisson B, Emile JF, Bigio B, Josephs JK, Seeleuthner Y, Martinez-Barricarte R, Markle JG, Itan Y, Kerner G, Jovic S, Wong N, Ikinciogullari A, Fleckenstein B, Bryant VL, Latorre D, Sallusto F, Dogu F, Migaud M, Tangye SG, Boisson-Dupuis S, Jabot-Hanin F, Surace L, Mansouri D, Avery DT, Okada S, Quintana-Murci L   +52 more
core   +1 more source

Interleukin-12 Peripheral Blood Levels in Asthmatic Children

Allergy, Asthma & Clinical Immunology, 2007
Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission.
Soferman Ruth, Rosenzwig Idit, Fireman Elizabeth   +2 more
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Development of IL-17A-associated autoimmunity [PDF]

, 2010
Autoimmunity results from a breakdown in tolerance to self-antigens. Interleukin-17A (IL-17A) is a cytokine that has been implicated in the development of certain autoimmune disorders, notably multiple sclerosis and its mouse model experimental ...
Hornsby, E.
core  

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Медицинская иммунология, 2014
.  The  aim  of  present  study  was  to  evaluate  clinical  and  prognostic  value  of  various  inflammationmarkers  in  patients  after  Q-wave  myocardial  infarction  (MI).
M. V. Zykov, O. L. Barbarash, V. V. Kashtalap, A. V. Veremeev, L. S. Barbarash   +4 more
doaj   +1 more source

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source