Results 81 to 90 of about 1,816,357 (289)

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

IL-12及IL-12P40对NK抗肿瘤功能的免疫调节

Zhongguo shiyan zhenduanxue, 2004
目的　通过对正常人及肿瘤患者血清中IL 12以及IL 12P4 0含量的检测 ,观察其分子对NK细胞抗肿瘤细胞细胞毒效应的影响 ,探讨IL 12、IL 12P4 0分子在NK细胞抗肿瘤功能上的免疫调节作用。方法　ELISA酶联免疫法检测IL 12、IL 12P4 0分泌水平以及MTT释放法检测NK细胞毒活性。结果　①肿瘤患者外周血PBMC中CD3+、CD5 6+细胞阳性率低于对照组 （P
张继英, 马安伦, 聂红, 柏峻, 余奇文, 张冬青   +5 more
doaj  

Role of Some Cytokines Among Infertile Women Undergoing Intracytoplasmic Sperm Injection

Medical Journal of Babylon
Background: Infertility is the incapacity to fulfill pregnancy after an appropriate time of sexual intercourse with no contraceptive measures taken. Ovulation disorders are one of the female factors that cause infertility, including polycystic ovarian ...
Dhuhaa Qasim Al-Faham, Abeer Thaher Naji Al Hasnawi, Ali Ibrahim Rahim Al-Dulaimi   +2 more
doaj   +1 more source

Semliki forest virus vectors engineered to express higher IL-12 levels induce efficient elimination of murine colon adenocarcinomas [PDF]

, 2005
To evaluate the use of alphavirus vectors for tumor treatment we have constructed and compared two Semliki Forest virus (SFV) vectors expressing different levels of IL-12.
Prieto, J. (Jesús), Rodriguez-Madoz, J.R. (Juan Roberto), Smerdou, C. (Cristian)   +2 more
core  

Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis [PDF]

, 2016
Differentiation and homeostasis of natural killer (NK) cells relies on common gamma-chain (γc)-dependent cytokines, in particular IL-15. Consequently, NK cells do not develop in mice with targeted γc deletion. Herein we identify an alternative pathway of
Arnold, SJ, Becher, B, Munz, C, Nussbaum, K, Ohs, I, Quezada, SA, Tugues, S, van den Broek, M   +7 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Upregulation of natural killer cells functions underlies the efficacy of intratumorally injected dendritic cells engineered to produce interleukin-12 [PDF]

, 2002
OBJECTIVE: Injection of dendritic cells (DC) engineered with recombinant adenoviral vectors to produce interleukin-12 (IL-12) inside experimental murine tumors frequently achieves complete regressions. In such a system the function of CD8(+) T cells has
Berraondo, P. (Pedro), Duarte, M. (Marina), Mazzolini, G. (Guillermo), Melero, I. (Ignacio), Prieto, J. (Jesús), Qian, C. (Cheng), Rodriguez-Calvillo, M. (Mercedes), Tirapu, I. (Íñigo)   +7 more
core   +1 more source

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Fingering IL-12 with Apoptotic Cells [PDF]

Immunity, 2004
Exposure of phosphatidylserine on the surface of apoptotic cells contributes to their removal in situ by quiet, noninflammatory, and nonimmunogenic mechanisms. In this issue of Immunity, describe a completely new mechanism for this effect that involves a novel zinc finger nuclear factor that inhibits IL-12 production.
openaire   +2 more sources