Results 101 to 110 of about 82,847,056 (224)

Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL [PDF]

open access: yes, 2010
Recently, gene-based cytokine treatment has been actively pursued as a new promising approach in treating cancer. In an effort to augment the efficiency of antitumor effect by cytokine-mediated immunotherapy, we selected both interleukin (IL)-12 and 4 ...
윤채옥   +15 more
core   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng   +3 more
wiley   +1 more source

Local expression of IL-12, IL-23, IFN-γ, and TNF-α in vivo.

open access: yes, 2013
Tumor tissue was obtained at 7 days after the first viral treatment. ELISA was performed to estimate the level of IL-12 (a), IL-23 (b), IFN-γ (c), and TNF-α (d) in tumor tissues. Experiments were carried out in triplicate and repeated three times.
Eonju Oh (430119)   +4 more
core   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida   +11 more
wiley   +1 more source

Opposing roles for IL-23 and IL-12 in maintaining occult cancer in an equilibrium state

open access: yes, 2012
Fulltext embargoed for: 12 months post date of publicationCancer immunoediting, the process by which the immune system controls tumor growth and shapes tumor immunogenicity, consists of 3 stages: elimination, equilibrium, and escape.
Duret, H   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

IL-12+IL-18 co-expression and low amounts of IL-12 cDNA reduce IL-12-side effects by decreasing TNFα expression.

open access: yes, 2014
B6 mice were treated with IL-12 cDNA alone (black circle), IL-12+IL-18 cDNA (open circle) or low IL-12 cDNA (0,5 µg) 2 days prior to administration of a high amount of IL-12 cDNA (5 µg) (black square).
Natalia S. Baez (528842)   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Il modello di business

open access: yes, 2011
Il capitolo presenta i risultati di un questionario rivolto agli intermediari bancari italiani che operano nel comparto del microcredito finalizzato ad indagare lo stato dell'arte di questo business (margini prodotti, modalità di valutazione del rischio,
PORRETTA, Pasqualina
core  

Nmunomodulación de Uncaria tomentosa sobre células dendríticas, il-12 y perfil TH1/TH2/TH17 en cáncer de mama

open access: yesRevista Peruana de Medicina Experimental y Salud Pública
Objetivos. Evaluar el efecto inmunomodulador del extracto estandarizado (5,03%, alcaloides oxindólicos pentacíclicos) de Uncaria tomentosa (UT-POA) sobre el inmunofenotipo de células dendríticas (DC) y IL-12/Th1/Th2/Th17 en pacientes con cáncer de mama ...
César Núñez   +5 more
doaj   +2 more sources

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