Enhanced gut barrier integrity sensitizes colon cancer to immune therapy
OncoImmunology, 2018 Oral IL-10 suppressed tumor growth in the APCmin/+ mouse/Bacteroides fragilis colon cancer model while a similar formulation of IL-12 exacerbated disease.
Neal Bhutiani +9 more
doaj +1 more source
Interleukin-12 Peripheral Blood Levels in Asthmatic Children
Allergy, Asthma & Clinical Immunology, 2007 Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission.
Soferman Ruth +2 more
doaj +1 more source
Efecto de la administración exógena de IL-12 en un modelo murino de enfermedad de injerto contra el huésped [PDF]
, 2005 Consultable des del TDXTítol obtingut de la portada digitalitzadaHemos analizado el efecto de la IL-12 sobre la enfermedad autoinmune en un modelo murino semialogénico de enfermedad crónica de injerto contra el huésped (EICHc) inducida en ratones (Balb/c
Gallego Valadés, Francisca
core +3 more sources
IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. [PDF]
, 2015 Gut homeostasis and mucosal immune defense rely on the differential contributions of dendritic cells (DC) and macrophages. Here we show that colonic CX3CR1(+) mononuclear phagocytes are critical inducers of the innate response to Citrobacter rodentium ...
Aychek, T +10 more
core +1 more source
Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek +13 more
wiley +1 more source
Learning From Success and Failure: Biologics for Non-approved Skin Diseases
Frontiers in Immunology, 2019 The impressive potential of biologics has been demonstrated in psoriasis, hidradenitis suppurativa, and urticaria. Numerous biologicals are entering the field for a restricted number of skin disorders.
Reinhart Speeckaert +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian +7 more
wiley +1 more source
Development of approaches for cellular immunotherapy of cancer patients
Медицинская иммунология, 2021 To treat the patients with oncological diseases, cellular immunotherapy have been actively developed in recent years. Usage of antitumor adoptive immunotherapy (AIT) based on in vitro activated lymphocytes and natural killer cells (NK cells) is the most ...
Yu. V. Gelm +3 more
doaj
Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas [PDF]
, 1999 Stimulation of the antitumor immune response by dendritic cells (DC) is critically dependent on their tightly regulated ability to produce interleukin-12 (IL-12).
Bustos, M. (Matilde) +8 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti +12 more
wiley +1 more source