Results 1 to 10 of about 1,546,418 (287)
Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]
Viruses, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
John Foerster, Aleksandra Molęda
doaj +4 more sources
In vitro potency and pharmacokinetics of APG777, a novel anti–IL-13 mAb [PDF]
Journal of Allergy and Clinical Immunology: GlobalBackground: IL-13 plays a key role in the induction and perpetuation of type 2 immune responses associated with the development of atopic dermatitis and other chronic inflammatory diseases.
Eric Zhu, PhD +8 more
doaj +2 more sources
IL-13 protects from Clostridioides difficile colitis. [PDF]
AnaerobeClostridioides difficile infection (CDI) is the leading hospital-acquired infection in North America. We have previously discovered that antibiotic disruption of the gut microbiota decreases intestinal IL-33 and IL-25 and increases susceptibility to CDI. We further found that IL-33 promotes protection through type 2 Innate Lymphoid Cells (ILC2s), which
Donlan AN +5 more
europepmc +3 more sources
Vaccines, 2021 We have shown that manipulation of IL-13 and STAT6 signaling at the vaccination site can lead to different innate lymphoid cell (ILC)/dendritic cell (DC) recruitment, resulting in high avidity/poly-functional T cells and effective antibody ...
Zheyi Li, Sreeja Roy, Charani Ranasinghe
doaj +1 more source
Vaccines, 2022 Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma.
Corrado Pelaia +8 more
doaj +1 more source
Interleukin-13 (IL-13) Pathway [PDF]
Science's STKE, 2005 Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T H 2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils.
Ann, Kelly-Welch +2 more
openaire +2 more sources
A Case of Papuloerythroderma Successfully Treated with Dupilumab
Case Reports in Dermatology, 2022 Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching.
Ayaka Mizuno +4 more
doaj +1 more source
IL-13 Signaling in Liver Fibrogenesis [PDF]
Frontiers in Immunology, 2012 Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g.
Yan eLiu +4 more
openaire +3 more sources
Respirology Case Reports, 2021 Dupilumab, a human monoclonal antibody against interleukin‐4 (IL‐4) and IL‐13, has been approved for treating severe asthma and eosinophilic chronic rhinosinusitis (ECRS).
Yoshiro Kai +6 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2022 The heterogeneous etiology of asthma makes its diagnosis complicated. Measurement of cytokine levels could be relevant in determining the asthma phenotype, predicting severity, and identifying the treatment type. Enzyme-linked immunosorbent assay (ELISA)
Sawsan M. Jabbar AL-Hasnawi +1 more
doaj +1 more source