Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of Gambian infants [PDF]
, 2008 Background There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective.
A Lalvani +46 more
core +6 more sources
IL‐13 signaling through IL‐13 receptor α2 mediates airway epithelial wound repair [PDF]
The FASEB Journal, 2018 ABSTRACT Asthma is an airway inflammatory disease characterized by epithelial barrier dysfunction and airway remodeling. Interleukin‐13 (IL‐13) is a pleiotropic cytokine shown to contribute to features of airway remodeling.
S Jasemine, Yang +4 more
openaire +2 more sources
IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma [PDF]
PeerJ, 2022 Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid.
Siti Muhamad Nur Husna +3 more
doaj +2 more sources
Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2 [PDF]
The Journal of Experimental Medicine, 2003 Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)α and IL-13Rα1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 ...
Wood, Nancy +12 more
openaire +2 more sources
IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]
, 2007 Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Bergner, Albrecht +5 more
core +1 more source
iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers
BMC Bioinformatics, 2023 Background Inflammatory mediators play havoc in several diseases including the novel Coronavirus disease 2019 (COVID-19) and generally correlate with the severity of the disease.
Pooja Arora +4 more
doaj +1 more source
Cells, 2023 Asthma is a chronic complex pulmonary disease characterized by airway inflammation, remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and eosinophil-derived neurotoxin (EDN) are two significant mediators involved in the ...
Maciej Tota +4 more
doaj +1 more source
Impact of Anti-Diabetic Treatments on Circulating Anti-Inflammatory Mediators (IL-10 and IL-13) in Type 2 Diabetes Patients [PDF]
Journal of Bioscience and Applied ResearchBackground and Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by persistent hyperglycemia and low-grade inflammation, involving cytokines like IL-10 and IL-13.
Muhannad Shweash +4 more
doaj +1 more source
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]
, 2015 Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay +6 more
core +2 more sources
Differential Effects of Alarmins on Human and Mouse Basophils
Frontiers in Immunology, 2022 Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella +17 more
doaj +1 more source