Results 21 to 30 of about 1,572,209 (287)

Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study

Autoimmunity, 2022
Introduction Asthma is a chronic lung disease that injures and constricts the airways. This study evaluates the effects of agmatine on ovalbumin (OVA)-induced allergic inflammation of the airways.
Mohammed K. Еlmahdy, Rania R. Abdelaziz, Hoda S. Elmahdi, Ghada M. Suddеk   +3 more
doaj   +1 more source

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Hamann, Jörg, Hoek, Robert M., Huitinga, Inge, Koning, Nathalie, Pouwels, Walter, Raes, Geert, van Eijk, Marco, Voehringer, David   +8 more
core   +1 more source

Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects [PDF]

, 2010
Background - Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required.
A. Geert Heidema, Edith J. M. Feskens, Johanna M. Geleijnse, Lisette C. P. G. M. de Groot, Lydia A. Afman, Marieke B. Bos, Michael Müller, Ondine van de Rest, Susan J. van Dijk   +8 more
core   +7 more sources

In vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma

Journal of Asthma and Allergy, 2021
Li Y Drake,1,2 Kathleen R Bartemes,1,3 Kay A Bachman,1 John B Hagan,1 Hirohito Kita1,4 1Division of Allergic Diseases and Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic ...
Drake LY, Bartemes KR, Bachman KA, Hagan JB, Kita H   +4 more
doaj  

Eosinophil-derived IL-13 promotes emphysema [PDF]

European Respiratory Journal, 2019
The inflammatory responses in chronic airway diseases leading to emphysema are not fully defined. We hypothesised that lung eosinophilia contributes to airspace enlargement in a mouse model and to emphysema in patients with chronic obstructive pulmonary disease (COPD). A transgenic mouse model of chronic type 2 pulmonary inflammation (
Alfred D. Doyle, Manali Mukherjee, William E. LeSuer, Tyler B. Bittner, Saif M. Pasha, Justin J. Frere, Joseph L. Neely, Jake A. Kloeber, Kelly P. Shim, Sergei I. Ochkur, Terence Ho, Sarah Svenningsen, Benjamin L. Wright, Matthew A. Rank, James J. Lee, Parameswaran Nair, Elizabeth A. Jacobsen   +16 more
openaire   +2 more sources

IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13 [PDF]

, 2008
Background: IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of ...
M Humbert, T Naseer, DS Robinson, SP Hogan, G Grunig, L Cohn, L Cohn, Z Zhu, Q Chen, R Leigh, M Yoshida, GK Hershey, D Kuperman, A Tomkinson, T Akimoto, DA Kuperman, H Ogata, MM Mentink-Kane, SO Rahaman, MO Daines, S Fichtner-Feigl, SP Hogan, O Tliba, K Espinosa, DS Faffe, PE Moore, S Zuyderduyn, SA Shore, Q Peng, V Govindaraju, G Grynkiewicz, J Kellner, JC Laporte, SJ Hirst, S Yamamoto, HL Dickensheets, NM Heller, T Sato, Z Huang, H Huang, J Ohara, F Syed, T Zheng, S Yasunaga, MO Daines, JA Losman, D Hebenstreit, H Dickensheets   +47 more
core   +3 more sources

Elimination of IL-13 Reverses Established Goblet Cell Metaplasia into Ciliated Epithelia in Airway Epithelial Cell Culture

Allergology International, 2006
Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea ...
Mitsuko Kondo, Jun Tamaoki, Kiyoshi Takeyama, Kazuo Isono, Kiyomi Kawatani, Takehiro Izumo, Atsushi Nagai   +6 more
doaj   +1 more source

IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung [PDF]

The Journal of Immunology, 2008
Abstract IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via a receptor complex, which contains IL-4Rα and IL-13Rα1. A third, high-affinity IL-13 receptor, IL-13Rα2, also exists. Although it was initially felt to be a decoy receptor, this has not been formally demonstrated and the ...
Tao, Zheng, Wei, Liu, Sun-Young, Oh, Zhou, Zhu, Buqu, Hu, Robert J, Homer, Lauren, Cohn, Michael J, Grusby, Jack A, Elias   +8 more
openaire   +2 more sources

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Computational and Structural Biotechnology Journal, 2023
Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13).
Urszula Plisak, Jarosław Szczepaniak, Magdalena Żmigrodzka, Beata Giercuszkiewicz-Hecold, Olga Witkowska-Piłaszewicz   +4 more
doaj   +1 more source