Results 41 to 50 of about 1,546,418 (287)

Elevated Gestational IL-13 During Fetal Development Is Associated With Hyperactivity and Inattention in Eight-Year-Old Children [PDF]

, 2019
Maternal immune activation (MIA) during fetal development leads to behavioral and psychological disorders in the offspring. Concomitantly, insufficient supply of polyunsaturated fatty acids (PUFAs) is suspected to contribute to early neuronal ...
Bergen, Martin von, Borte, Michael, Herberth, Gunda, Lehmann, Irina, Rolle-Kampczyk, Ulrike, Röder, Stefan, Thürmann, Loreen, Trump, Saskia   +7 more
core   +1 more source

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain

Respiratory Research, 2002
Background Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared.
Braun Sandra, Kruse Susanne, Deichmann Klaus A   +2 more
doaj   +1 more source

The Sera levels of Interleukin-13 in Patients with Atopic Dermatitis in Thi-Qar province

مجلة علوم ذي قار, 2022
The Interleukin-13 (IL-13) is a component of the innate immune system that is primarily produced by Th2 cells and is found in high concentrations in skin lesions of atopic dermatitis.
Amel A. Naji, Hind M Mousa
doaj   +1 more source

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis [PDF]

, 2012
Mast cell (MC) granules contain large amounts of proteases of the chymase, tryptase and carboxypeptidase A (MC-CPA) type that are stored in complex with serglycin, a proteoglycan with heparin side chains.
Feyerabend, TB, Hellman, L, Karlsson, Iulia, Pejler, Gunnar, Rodewald, HR, Schlenner, SM, Waern, Ida, Wernersson, Sara, Åbrink, Magnus   +8 more
core   +1 more source

Therapeutic Effect of Curcumin on Dermatitis Induced by Acetone in Female Rats

Kufa Journal for Veterinary Medical Sciences, 2023
The aim of this study was to evaluate different concertation of curcumin on induced atopic dermatitis in female Albino rats, particularly, immunomodulatory effect of curcumin in induced dermatitis by pure acetone 99.9% in female rats.
Ameer Al Fatlawy, Shatha Mousa Mlaghee
doaj   +1 more source

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. [PDF]

, 2017
Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear.
Akdis, C.A., Baerlocher, G.M., Basso, G., Bohner, P., Bruni, E., Carlo-Stella, C., Chevalier, M.F., Ciceri, F., Coukos, G., Curti, A., Derré, L., Falvo, P., Gfeller, D., Giarin, E., Girotra, M., Gomez-Cadena, A., Grandclément, C., Jandus, C., Lecciso, M., Leibundgut, E.O., Marcenaro, E., Martinez-Usatorre, A., Mavilio, D., Mazzarella, L., McKenzie, ANJ, Minucci, S., Morita, H., Pallavi, R., Papayannidis, C., Pelicci, P.G., Pizzitola, I., Racle, J., Rambaldi, A., Salomé, B., Salvestrini, V., Santoro, A., Spinelli, O., Taurino, D., Trabanelli, S., Tresoldi, C., Vanhecke, D., Verdeil, G.   +41 more
core   +8 more sources

The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma

Biomolecules
Bronchial asthma is characterized by airway inflammation, airway hyperresponsiveness, and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway disease mainly by releasing eosinophil-specific granules, lipid mediators ...
Kazuyuki Nakagome, Makoto Nagata
doaj   +1 more source

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Frontiers in Immunology, 2020
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert   +15 more
doaj   +1 more source

Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets

Frontiers in Pharmacology, 2022
Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia, Enrico Heffler, Enrico Heffler, Claudia Crimi, Angelantonio Maglio, Alessandro Vatrella, Girolamo Pelaia, Giorgio Walter Canonica, Giorgio Walter Canonica   +8 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source