Results 41 to 50 of about 1,572,209 (287)

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis [PDF]

, 2012
Mast cell (MC) granules contain large amounts of proteases of the chymase, tryptase and carboxypeptidase A (MC-CPA) type that are stored in complex with serglycin, a proteoglycan with heparin side chains.
Feyerabend, TB, Hellman, L, Karlsson, Iulia, Pejler, Gunnar, Rodewald, HR, Schlenner, SM, Waern, Ida, Wernersson, Sara, Åbrink, Magnus   +8 more
core   +1 more source

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain

Respiratory Research, 2002
Background Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared.
Braun Sandra, Kruse Susanne, Deichmann Klaus A   +2 more
doaj   +1 more source

The Sera levels of Interleukin-13 in Patients with Atopic Dermatitis in Thi-Qar province

مجلة علوم ذي قار, 2022
The Interleukin-13 (IL-13) is a component of the innate immune system that is primarily produced by Th2 cells and is found in high concentrations in skin lesions of atopic dermatitis.
Amel A. Naji, Hind M Mousa
doaj   +1 more source

ILC2-modulated T cell-to-MDSC balance is associated with bladder cancer recurrence. [PDF]

, 2017
Non-muscle-invasive bladder cancer (NMIBC) is a highly recurrent tumor despite intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine.
Anne-Sophie Fritschi, Bie, Biot, Bouchery, Bérengère Salomé, Camilla Jandus, Carrega, Cyrill A. Rentsch, Dalila Gharbi, Daniel E. Speiser, David Gfeller, Denise Nardelli-Haefliger, Florence Dartiguenave, Julien Racle, Laurent Derré, Lechner, Luo, Magazin, Mathieu F. Chevalier, Messing, Moro, Muthuswamy, Nightingale, Patrice Jichlinski, Perrine Bohner, Piehler, Sara Trabanelli, Sonia Domingos-Pereira, Tang, Valérie Cesson   +29 more
core   +3 more sources

Elevated Gestational IL-13 During Fetal Development Is Associated With Hyperactivity and Inattention in Eight-Year-Old Children [PDF]

, 2019
Maternal immune activation (MIA) during fetal development leads to behavioral and psychological disorders in the offspring. Concomitantly, insufficient supply of polyunsaturated fatty acids (PUFAs) is suspected to contribute to early neuronal ...
Bergen, Martin von, Borte, Michael, Herberth, Gunda, Lehmann, Irina, Rolle-Kampczyk, Ulrike, Röder, Stefan, Thürmann, Loreen, Trump, Saskia   +7 more
core   +1 more source

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Frontiers in Immunology, 2020
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert   +15 more
doaj   +1 more source

The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma

Biomolecules
Bronchial asthma is characterized by airway inflammation, airway hyperresponsiveness, and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway disease mainly by releasing eosinophil-specific granules, lipid mediators ...
Kazuyuki Nakagome, Makoto Nagata
doaj   +1 more source

Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells [PDF]

, 2018
Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed.
Branchett, WJ, Buckley, JS, Bush, A, Byrne, A, Denney, L, Entwhistle, LJ, Fainardi, V, Gregory, LG, Grychtol, R, Lloyd, CM, Lui, S, Manghera, AK, Oliver, RA, Puttur, F, Saglani, S, Sherburn, R, Uwadiae, F, Vasiliou, JE, von Mutius, E, Vöhringer, D, Walker, SA   +20 more
core   +2 more sources

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. [PDF]

, 2017
Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear.
Akdis, C.A., Baerlocher, G.M., Basso, G., Bohner, P., Bruni, E., Carlo-Stella, C., Chevalier, M.F., Ciceri, F., Coukos, G., Curti, A., Derré, L., Falvo, P., Gfeller, D., Giarin, E., Girotra, M., Gomez-Cadena, A., Grandclément, C., Jandus, C., Lecciso, M., Leibundgut, E.O., Marcenaro, E., Martinez-Usatorre, A., Mavilio, D., Mazzarella, L., McKenzie, ANJ, Minucci, S., Morita, H., Pallavi, R., Papayannidis, C., Pelicci, P.G., Pizzitola, I., Racle, J., Rambaldi, A., Salomé, B., Salvestrini, V., Santoro, A., Spinelli, O., Taurino, D., Trabanelli, S., Tresoldi, C., Vanhecke, D., Verdeil, G.   +41 more
core   +8 more sources