Results 61 to 70 of about 1,546,418 (287)

IL-13/IL-13 Receptor Interaction, an Emerging Therapeutic Target in Allergic Disease

Allergology International, 2005
ABSTRACTInterleukin (IL)-13 is a Th-2 cytokine, known to be involved in allergic diseases. Although IL-13 and another Th- 2 cytokine, IL-4, share receptors and signal pathways, having similar biological properties, the critical role of IL- 13 alone in vivo in the pathogenesis of bronchial asthma has recently been recognized, based mainly on analyses of
Arima, Kazuhiko, Izuhara, Kenji
openaire   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Immune mechanisms of atopic dermatitis and new approaches to targeted biological therapy

Медицинский совет, 2022
This review presents current data on immunopathogenesis, the role of cytokines in inflammation in atopic dermatitis (AD). The pathogenetic phenotypes of the disease associated with various abnormalities of immune mechanisms and dysfunction of the ...
N. N. Potekaev, G. P. Tereshchenko, R. A. Khanferyan, A. L. Savastenko   +3 more
doaj   +1 more source

Development of reagents to study the turkey's immune response:cloning and characterisation of two turkey cytokines, interleukin (IL)-10 and IL-13 [PDF]

, 2012
The cDNAs of two turkey cytokines, interleukin (IL)-10 and IL-13, were cloned using oligonucleotide primers designed from their chicken orthologues. The coding regions of the chicken and turkey genes are highly conserved, with IL-10 and IL-13 exhibiting ...
Clarkson, Michael, Kaiser, Pete, Powell, Fiona, Rothwell, Lisa   +3 more
core   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production [PDF]

Journal of Allergy and Clinical Immunology, 2011
IL-13 is a central mediator of airway responsiveness and mucus expression in patients with allergic airway inflammation, and IL-13 is currently a therapeutic target for asthma. However, little is known about how IL-13 regulates human CD4(+) T-cell lineages because IL-13 receptor (IL-13R) α1, a subunit of IL-13R, has not previously been reported to ...
Dawn C, Newcomb, Madison G, Boswell, Weisong, Zhou, Matthew M, Huckabee, Kasia, Goleniewska, Carla M, Sevin, Gurjit K Khurana, Hershey, Jay K, Kolls, R Stokes, Peebles   +8 more
openaire   +2 more sources

The Major Soybean Allergen Gly m Bd 28K Induces Hypersensitivity Reactions in Mice Sensitized to Cow's Milk Proteins [PDF]

, 2016
Reactions to soy have been reported in a proportion of patients with IgE-mediated cow’s milk allergy (CMA). In this work, we analyzed if Gly m Bd 28K/P28, one of the major soybean allergens, is a cross-reactive allergen with cow milk proteins (CMP).
Candreva, Ángela María, Curciarello, Renata, Docena, Guillermo H., Fossati, Carlos Alberto, Petruccelli, Silvana, Smaldini, Paola Lorena   +5 more
core   +2 more sources

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

IL-13 Antibodies Influence IL-13 Clearance in Humans by Modulating Scavenger Activity of IL-13Rα2 [PDF]

The Journal of Immunology, 2011
Abstract Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a clinically significant impact on clearance of IL-13. We propose that Ab modulation of IL-13 interaction with IL-13Rα2 underlies this effect. Two Abs were administered to healthy subjects and mild asthmatics in
Marion T, Kasaian, Donald, Raible, Kimberly, Marquette, Timothy A, Cook, Simon, Zhou, Xiang-Yang, Tan, Lioudmila, Tchistiakova   +6 more
openaire   +2 more sources

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]

, 2016
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank, Barrett, Nora A, Kanaoka, Yoshihide, Locksley, Richard M, O'Leary, Claire E, von Moltke, Jakob   +5 more
core   +1 more source