Results 61 to 70 of about 1,572,209 (287)

IL-13/IL-13 Receptor Interaction, an Emerging Therapeutic Target in Allergic Disease

Allergology International, 2005
ABSTRACTInterleukin (IL)-13 is a Th-2 cytokine, known to be involved in allergic diseases. Although IL-13 and another Th- 2 cytokine, IL-4, share receptors and signal pathways, having similar biological properties, the critical role of IL- 13 alone in vivo in the pathogenesis of bronchial asthma has recently been recognized, based mainly on analyses of
Arima, Kazuhiko, Izuhara, Kenji
openaire   +1 more source

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Pharmaceutical Biology, 2021
Context Sargassum horneri (Turner) C. Agardh (Sargassaceae) is a brown marine alga used in oriental medicine to treat allergic conditions. Objective This study clarifies the effect of polyphenol-containing S.
Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Hyo Jin Kim, Duong Thi Thuy Dinh, Hyun-Soo Kim, Ginnae Ahn, You-Jin Jeon, Youngheun Jee   +7 more
doaj   +1 more source

Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets

Frontiers in Pharmacology, 2022
Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia, Enrico Heffler, Enrico Heffler, Claudia Crimi, Angelantonio Maglio, Alessandro Vatrella, Girolamo Pelaia, Giorgio Walter Canonica, Giorgio Walter Canonica   +8 more
doaj   +1 more source

CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children [PDF]

, 2005
In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and interleukin (IL)-13 seems to play a pivotal role in the inflammatory network. We tried to assess the correlation between the immunological marker CD4(+)IL-13(+) and the clinical phase ...
CITARRELLA, Roberto, GIORDANO, Carla, LA GRUTTA, Stefania, MATTINA, Antonina, Pajno, G., PASSALACQUA, Girolamo, PIZZOLANTI, Giuseppe, RICHIUSA, Pierina   +7 more
core   +1 more source

Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production [PDF]

Journal of Allergy and Clinical Immunology, 2011
IL-13 is a central mediator of airway responsiveness and mucus expression in patients with allergic airway inflammation, and IL-13 is currently a therapeutic target for asthma. However, little is known about how IL-13 regulates human CD4(+) T-cell lineages because IL-13 receptor (IL-13R) α1, a subunit of IL-13R, has not previously been reported to ...
Dawn C, Newcomb, Madison G, Boswell, Weisong, Zhou, Matthew M, Huckabee, Kasia, Goleniewska, Carla M, Sevin, Gurjit K Khurana, Hershey, Jay K, Kolls, R Stokes, Peebles   +8 more
openaire   +2 more sources

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

IL-13 Antibodies Influence IL-13 Clearance in Humans by Modulating Scavenger Activity of IL-13Rα2 [PDF]

The Journal of Immunology, 2011
Abstract Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a clinically significant impact on clearance of IL-13. We propose that Ab modulation of IL-13 interaction with IL-13Rα2 underlies this effect. Two Abs were administered to healthy subjects and mild asthmatics in
Marion T, Kasaian, Donald, Raible, Kimberly, Marquette, Timothy A, Cook, Simon, Zhou, Xiang-Yang, Tan, Lioudmila, Tchistiakova   +6 more
openaire   +2 more sources

Development of reagents to study the turkey's immune response:cloning and characterisation of two turkey cytokines, interleukin (IL)-10 and IL-13 [PDF]

, 2012
The cDNAs of two turkey cytokines, interleukin (IL)-10 and IL-13, were cloned using oligonucleotide primers designed from their chicken orthologues. The coding regions of the chicken and turkey genes are highly conserved, with IL-10 and IL-13 exhibiting ...
Clarkson, Michael, Kaiser, Pete, Powell, Fiona, Rothwell, Lisa   +3 more
core   +1 more source