Results 251 to 260 of about 69,683,828 (280)
Some of the next articles are maybe not open access.
Immunotherapeutic Applications of IL-15
Immunotherapy, 2012IL-15 is a member of the IL-2 family of cytokines, which play a fundamental role in innate and adaptive immune responses. IL-15 has pleiotropic immune-enhancing activities, as it stimulates NK, T and NKT cell proliferation, survival and effector functions. In view of these properties, IL-15 is regarded as a good candidate for cancer immunotherapy. This
Michela, Croce +3 more
openaire +2 more sources
IL-15/IL-15 receptor biology: A guided tour through an expanding universe
Cytokine & Growth Factor Reviews, 2006The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling.
Budagian, Vadim +3 more
openaire +2 more sources
Nature Medicine, 2007
Mice deficient for the cytokine interleukin-15 are unexpectedly protected from sepsis. Orinska and colleagues show that interleukin-15 signals intracellularly in mast cells and limits their recruitment of neutrophils to clear the infection (pages 927–934).
openaire +1 more source
Mice deficient for the cytokine interleukin-15 are unexpectedly protected from sepsis. Orinska and colleagues show that interleukin-15 signals intracellularly in mast cells and limits their recruitment of neutrophils to clear the infection (pages 927–934).
openaire +1 more source
MACRO- AND MICROCIRCULATORY EFFECTS OF IL-15
Shock, 1995The recently isolated and cloned cytokine interleukin (IL)-15 was studied to ascertain its systemic and local cardiovascular effects. IL-15 was studied in rats anesthetized with 50 mg/kg sodium pentobarbital. In Group I, 10-50 micrograms of IL-15 were administered intravenously.
C H, Baker, F L, Abel
openaire +2 more sources
Blood, 2006
Comment on Blaser et al, page [2463][1] Recent studies suggest that the effects of IL-15 are enhanced when IL-15–secreting cells also express the IL-15Rα receptor subunit. Trans -presentation of IL-15 promotes localized immunologic functions that are distinct from IL-2. Interleukin-2 (IL-2)
openaire +1 more source
Comment on Blaser et al, page [2463][1] Recent studies suggest that the effects of IL-15 are enhanced when IL-15–secreting cells also express the IL-15Rα receptor subunit. Trans -presentation of IL-15 promotes localized immunologic functions that are distinct from IL-2. Interleukin-2 (IL-2)
openaire +1 more source
IL-15/IL-15Rα komplexy jako superagonisté IL-15
2017Interleukin 15 binds to its hight-afinity receptor IL-15Rα and forms stable IL-15/IL-15Rα complexes. IL-15Rα presents IL-15 in trans to target CD122/CD132 cells, where initiates signal transduction. Interleukin 15 has important role in immune system as it - regulates the homeostatic proliferation of memory CD8+ T cells and it is an essential for ...
openaire +1 more source