Results 1 to 10 of about 5,540,448 (336)
IL-17 and IL-17-producing cells in protection versus pathology
Nature Reviews Immunology, 2022 IL-17 cytokines drive biological responses that protect the host against many infections but can also contribute to host pathology in the context of infection and autoimmunity.
K. Mills
semanticscholar +5 more sources
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
Frontiers in Immunology, 2021 Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
Claudia Schinocca +6 more
doaj +2 more sources
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
Frontiers in Immunology, 2020 Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells.
Taoming Liu +7 more
doaj +2 more sources
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides [PDF]
Journal of Experimental Medicine, 2006 Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family member, at substantially higher amounts than T helper (Th)1 or Th2 ...
Spencer C. Liang +6 more
openalex +2 more sources
IL-17 in the immunopathogenesis of spondyloarthritis [PDF]
Nature Reviews Rheumatology, 2018 Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical and immunological features, including joint inflammation (peripheral and axial skeleton ...
L. Taams +4 more
semanticscholar +7 more sources
Journal of Allergy and Clinical Immunology, 2004 A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo , and have been shown to ...
Mio Kawaguchi +4 more
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The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells [PDF]
Cell, 2006 Ivaylo I. Ivanov +7 more
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The IL-17 family in diseases: from bench to bedside
Signal Transduction and Targeted Therapy, 2023 The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago.
Longjie Huangfu +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati +9 more
doaj +1 more source
Protocol for the safety of brodalumab regarding psychiatric comorbidities in patients with psoriasis
European Psychiatry, 2022 Introduction Brodalumab, an anti-IL17RA monoclonal antibody, is a treatment option for plaque psoriasis related to increased risk of suicidal ideation and behavior, including completed suicide.However, in the literature no causal relationship is ...
O. Pikou +4 more
doaj +1 more source