Results 31 to 40 of about 5,540,448 (336)
Cellular Immunology, 2019 Interleukin-17 (IL-17) is a potent proinflammatory cytokine that protects a host against fungal and extracellular bacterial infections. On the other hand, excessive or dysregulated production of IL-17 underlines susceptibility to autoimmune disease. Consequently, blocking IL-17 has become an effective strategy for modulating several autoimmune diseases,
Adebola Giwa +4 more
openaire +4 more sources
Bimekizumab for the Treatment of Psoriasis: A Review of the Current Knowledge
Psoriasis: Targets and Therapy, 2022 Angelo Ruggiero, Luca Potestio, Elisa Camela Snr, Gabriella Fabbrocini, Matteo Megna Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, ItalyCorrespondence: Angelo Ruggiero, Section of ...
Ruggiero A +4 more
doaj
Nature Communications, 2020 Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper ...
Yun Liao +16 more
semanticscholar +1 more source
The role of IL-17 in psoriasis
Journal of Dermatological Treatment, 2014 Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis ...
Ethan Levin +4 more
openaire +3 more sources
Ekstrak Etanol Propolis Menurunkan Kadar IL-17 Serum pada Mencit Balb/C Model Asma Kronik
Majalah Kedokteran Bandung, 2013 Interleukin-17 (IL-17) induces the neutrophil recruitment into the respiratory tract while playing a role in the pathogenesis of asthma and determining the severity of disease.
Sri Hartati Hadinoto +3 more
doaj +1 more source
Frontiers in Immunology, 2021 This is a case series study to evaluate immunological markers associated with schistosomiasis advanced fibrosis, including 69 patients from an endemic area from the State of Sergipe and from the Hepatology Service of the University Hospital in Sergipe ...
Karine Garcez Schuster Franco +36 more
doaj +1 more source
Cell, 2016 IL-17A both directly induces and synergizes with other cytokines to promote autoimmune tissue inflammation. Secukinumab and ixekizumab are monoclonal antibodies (mAb) that inhibit interleukin-17A. These two agents were recently approved for treatment of psoriasis, and secukinumab is also approved for treatment of two spondyloarthropathies, psoriatic ...
Vijay K. Kuchroo, Patrick R. Burkett
openaire +3 more sources
Mini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis
Frontiers in Pharmacology, 2019 Psoriasis, an inflammatory skin disease, and psoriatic arthritis (PsA), an inflammatory arthritis, share clinical, genetic, and pathogenic factors and may be summed as one disease, the psoriatic disease.
Lazaros I. Sakkas +2 more
doaj +1 more source
OncoImmunology, 2023 IL-17 immune responses in cancer are controversial, with both tumor-promoting and tumor-repressing effects observed. To clarify the role of IL-17 signaling in cancer progression, we used syngeneic tumor models from different tissue origins. We found that
Constanza Rodriguez +13 more
doaj +1 more source
IL‐17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa
Clinical and Experimental Immunology, 2020 The skin is one of the most important organs in the body, providing integrity and acting as a barrier to exclude microbes, allergens and chemicals. However, chronic skin inflammation can result when barrier function is defective and immune responses are ...
J. Fletcher +3 more
semanticscholar +1 more source