Results 61 to 70 of about 5,540,448 (336)

The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond

Frontiers in Immunology, 2018
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been recently licensed or are in clinical development.
N. Brembilla, L. Senra, W. Boehncke
semanticscholar   +1 more source

Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation

FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.
Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese, Laura A. Hansen, Sándor Lovas   +2 more
wiley   +1 more source

Increased Levels of Interleukin-17A Exosomes in Psoriasis

Acta Dermato-Venereologica, 2019
Exosomes are involved in modulating the immune system and mediating communication between cells. The aim of this study was to investigate the involvement of exosomes in psoriasis.
Claire Jacquin-Porretaz, Marine Cordonnier, Charlée Nardin, Laura Boullerot, Gaetan Chanteloup, Valentin Vautrot, Olivier Adotevi, Carmen Garrido, Jessica Gobbo, François Aubin   +9 more
doaj   +1 more source

A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It

Frontiers in Immunology, 2018
Neutrophils are known to perform a series of effector functions that are crucial for the innate and adaptive responses, including the synthesis and secretion of a variety of cytokines.
Nicola Tamassia, Fabio Arruda-Silva, Fabio Arruda-Silva, Federica Calzetti, Silvia Lonardi, Sara Gasperini, Elisa Gardiman, Francisco Bianchetto-Aguilera, Luisa Benerini Gatta, Giampiero Girolomoni, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, William Vermi, Marco A. Cassatella   +14 more
doaj   +1 more source

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

Science immunology, 2019
Meningeal γδ T cells are biased toward IL-17 production and control hippocampal synaptic plasticity and short-term memory. T cells that promote memories There is now a growing appreciation of cross-talk between the nervous and immune systems.
M. Ribeiro, Helena C. Brigas, Mariana Temido-Ferreira, Paula A. Pousinha, Tommy Regen, C. Santa, J. Coelho, Inês Marques-Morgado, C. Valente, Sara Omenetti, B. Stockinger, A. Waisman, B. Manadas, Luísa V. Lopes, B. Silva-Santos, J. Ribot   +15 more
semanticscholar   +1 more source

Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5

FEBS Letters, Volume 599, Issue 6, Page 866-875, March 2025.
The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu, Joonho Yoon, Eunyoung Lee, Audrey N. Chang, R. Tyler Miller   +4 more
wiley   +1 more source

Clinical utility of ixekizumab in the treatment of moderate-to-severe plaque psoriasis

Psoriasis: Targets and Therapy, 2017
Sahil Sekhon, Caleb Jeon, Mio Nakamura, Di Yan, Ladan Afifi, Tina Bhutani, Ethan Levin Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA Abstract: Psoriasis vulgaris is a chronic ...
Sekhon S, Jeon C, Nakamura M, Yan D, Afifi L, Bhutani T, Levin E   +6 more
doaj  

Role of interleukin 17 (IL-17) in the inflammatory hypothesis of depression

Journal of Affective Disorders Reports, 2023
Depression is one of the most common mental disorders. Despite its high prevalence, the etiopathogenesis of depression is not yet fully understood. Only around 1/3 of depressed patients remit in response to standard antidepressant treatment.
Katarzyna Bliźniewska-Kowalska, Angelos Halaris, Piotr Gałecki, Małgorzata Gałecka   +3 more
doaj  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source