Results 91 to 100 of about 1,564,564 (287)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment

Frontiers in Medicine
ObjectiveThis study aimed to explore the relationship between serum levels of interleukin-17 (IL-17), interleukin-18 (IL-18), interleukin-22 (IL-22), interleukin-25 (IL-25), anti-BP180 antibodies, anti-BP230 antibodies, and immunoglobulin E (IgE) and the
Xinyi Hong, Xinyi Hong, Xinyi Hong, Xinyi Hong, Xiuqin Wang, Xiuqin Wang, Xiuqin Wang, Xiuqin Wang, Yin Cheng, Yin Cheng, Yin Cheng, Yin Cheng, Hanqing Song, Hanqing Song, Hanqing Song, Hanqing Song, Congcong Xu, Congcong Xu, Congcong Xu, Congcong Xu, Peiguang Wang, Peiguang Wang, Peiguang Wang, Peiguang Wang   +23 more
doaj   +1 more source

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis [PDF]

, 2014
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease leading to the death of affected individuals within years. The involvement of inflammation in the pathogenesis of neurodegenerative diseases, including ALS, is ...
Barbara Borroni, Cecilia Carlesi, Diana Boraschi, Gabriele Siciliano, Ilaria Puxeddu, Paola Bossù, Paola Giungato, Paola Italiani, Paola Migliorini   +8 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma [PDF]

Exploration of Medicine
Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction.
Regina N. Khramova, Elena V. Tush, Tatyana I. Eliseeva, Dmitriy Yu. Ovsyannikov, Svetlana V. Krasilnikova, Maxim A. Karpenko, Natalia A. Geppe, Nailya I. Kubysheva, Olga V. Khaletskaya   +8 more
doaj   +1 more source

IL-18 promoter polymorphisms under scrutiny [PDF]

Inflammation Research, 2014
In their recent contribution to this journal, Li and coworkers investigated the pooled effects of two IL-18 gene variants in periodontitis. Based on data from 576 cases and 458 controls, they claim significant associations for both variants with the phenotype under study. At closer inspection, however, this claim is not tenable.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The effect of swimming training and detraining on interleukin-17 and interleukin-18 of rats [PDF]

, 2017
Background and aims: Interleukin-17 (IL-17) and interleukin-18 (IL-18) are proinflammatory cytokines. The aim of the present study was to investigate the effect of swimming trainings and detraining on IL-17 and IL-18 of rats.
araiesh, Ameneh., Hassanpour, Qobad., Hosseini, Ali., Hosseini, Zahrasadat., Kheirdeh, Maryam., Noura, Mahdi.   +5 more
core  

Interleukin-18 produced by bone marrow- derived stromal cells supports T-cell acute leukaemia progression [PDF]

, 2014
International audienceDevelopment of novel therapies is critical for T-cell acute leukae-mia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70%
André Baruchel, Bastien Gerby, Benjamin Uzan, Caroline Deswarte, Ching‐Lien Wu, Corinne Besnard‐Guérin, Diana Passaro, Florence Armstrong, Florent Dumont, Francoise Pflumio, Francoise Porteu, Frédéric Baleydier, Jacques Ghysdael, Judith Landman‐Parker, Julia Gross, Julien Calvo, Paola Ballerini, Park S, Sandrine Poglio, Thierry Leblanc, Véronique Baud, Wadman IA, Xavier Cahu   +22 more
core   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source