Results 11 to 20 of about 1,073,186 (289)

IL-27 Regulates IL-18 binding protein in skin resident cells. [PDF]

PLoS One, 2012
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased IL-18 activity.
Wittmann M, Doble R, Bachmann M, Pfeilschifter J, Werfel T, Mühl H.   +5 more
europepmc   +9 more sources

Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma [PDF]

Mediators of Inflammation, 2014
Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian tissues.
Liat Medina, Alex Rabinovich, Benjamin Piura, Victor Dyomin, Ruthy Shaco Levy, Mahmoud Huleihel   +5 more
openaire   +3 more sources

Cloning and characterization of giant panda (Ailuropoda melanoleuca) IL-18 binding protein. [PDF]

Res Vet Sci, 2016
The giant panda (Ailuropoda melanoleuca) is an endangered species. Interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses by inducing IFN-γ. IL-18 has been implicated in the pathogenesis of various diseases. IL-18 binding protein (IL-18BP) is an intrinsic inhibitor of IL-18 that possesses higher affinity to IL-18. In
Yan Y, Deng J, Niu L, Wang Q, Yu J, Shao H, Cao Q, Zhang Y, Tan X.   +8 more
europepmc   +3 more sources

[Clinical significance of IL-18 and IL-18-binding protein in bone marrow of patients with myelodysplastic syndrome]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Objective: To analyze the level and clinical significance of IL-18 and IL-18-binding protein (BP) in the bone marrow of patients with myelodysplastic syndrome (MDS) . Methods: A total of 43 newly diagnosed patients with MDS who were admitted to the Department of Hematology, Tianjin Medical University General Hospital, from July 2020 to February 2021 ...
Wang T, Ran NY, Chen QL, Liu DL, Zang MT, Li NB, He X, Guan J, Fu R, Shao ZH.   +9 more
europepmc   +3 more sources

Pharmacokinetic Study of rhIL-18BP and Its Effect on Radiation-Induced Cytokine Changes in Mouse Serum and Intestine

Toxics, 2022
Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui, Lisa Hull, Alex Zizzo, Li Wang, Bin Lin, Min Zhai, Mang Xiao   +6 more
doaj   +1 more source

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Frontiers in Immunology, 2023
Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang, Xiaoyun Wang, Lian Wang, Xiang Wen, Lu Zhang, Xian Jiang, Xian Jiang, Gu He, Gu He   +8 more
doaj   +1 more source

Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis. [PDF]

Cell Rep Med
Summary: Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease characterized by inflammation and fibrosis, with enhanced interleukin-18 (IL-18) signaling. IL-18-binding protein (IL-18BP) neutralizes IL-18, but its therapeutic
Kim DH, Choi G, Song EB, Lee H, Kim J, Jang YS, Park J, Chi S, Han J, Kim SM, Kim D, Bae SH, Lee HW, Park JY, Kang SG, Cha SH, Han YH.   +16 more
europepmc   +2 more sources

IL-18 Binding Protein Protects Against Contact Hypersensitivity [PDF]

The Journal of Immunology, 2003
AbstractAllergic contact dermatitis, the clinical manifestation of contact hypersensitivity, is one of the most common disorders of the skin. It is elicited upon multiple cutaneous re-exposure of sensitized individuals to the sensitizing agent. In this study, we demonstrate that using IL-18 binding protein (IL-18BP) to neutralize IL-18 significantly ...
Thomas, Plitz, Pierre, Saint-Mézard, Masataka, Satho, Susanne, Herren, Caroline, Waltzinger, Marcelo, de Carvalho Bittencourt, Marie H, Kosco-Vilbois, Yolande, Chvatchko   +7 more
openaire   +2 more sources

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

mAbs, 2023
Here, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ.
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka   +16 more
doaj   +1 more source

Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis [PDF]

, 2020
Abstract Background: Interleukin (IL)-18 is emerging as an attractive participant in allergic rhinitis (AR). However, correlation of IL-18 with IL-18 binding protein (BP) in plasma, and expression of IL-18, IL-18BP and IL-18 receptor (R) in AR blood monocytes remain obscure.Methods: We investigated IL-18, IL-18BP and IL-18R expression in ...
Junling Wang, Fangqiu Gu, Zhi Li, Mengmeng Zhan, Ling Wang, Huiyun Zhang, Dong Chen, Hua Xie, Ruonan Chai, Nan Zhao, Ruiming Yang, Yalin Hu, Shaoheng He   +12 more
openaire   +3 more sources